LRRN2

Leucine-rich repeat neuronal protein 2 is a protein that in humans is encoded by the LRRN2 gene.[5][6]

LRRN2
Identifiers
AliasesLRRN2, FIGLER7, GAC1, LRANK1, LRRN5, leucine rich repeat neuronal 2
External IDsOMIM: 605492 MGI: 106037 HomoloGene: 21274 GeneCards: LRRN2
Orthologs
SpeciesHumanMouse
Entrez

10446

16980

Ensembl

ENSG00000170382

ENSMUSG00000026443

UniProt

O75325

Q6PHP6

RefSeq (mRNA)

NM_006338
NM_201630

NM_010732

RefSeq (protein)

NP_006329
NP_963924

NP_034862

Location (UCSC)Chr 1: 204.62 – 204.69 MbChr 1: 132.81 – 132.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000170382 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026443 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Almeida A, Zhu XX, Vogt N, Tyagi R, Muleris M, Dutrillaux AM, Dutrillaux B, Ross D, Malfoy B, Hanash S (Aug 1998). "GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas". Oncogene. 16 (23): 2997–3002. doi:10.1038/sj.onc.1201828. PMID 9662332.
  6. "Entrez Gene: LRRN2 leucine rich repeat neuronal 2".

Further reading


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