LSM6

U6 snRNA-associated Sm-like protein LSm6 is a protein that in humans is encoded by the LSM6 gene.[5][6][7]

LSM6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLSM6, YDR378C, LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDsOMIM: 607286 MGI: 1925901 HomoloGene: 38271 GeneCards: LSM6
Orthologs
SpeciesHumanMouse
Entrez

11157

78651

Ensembl

ENSG00000164167

ENSMUSG00000031683

UniProt

P62312

P62313

RefSeq (mRNA)

NM_007080

NM_001191004
NM_030145

RefSeq (protein)

NP_009011

NP_001177933
NP_084421

Location (UCSC)Chr 4: 146.18 – 146.2 MbChr 8: 79.53 – 79.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop.

The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000164167 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031683 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
  6. Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
  7. "Entrez Gene: LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)".

Further reading

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