LUC7L3

LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene.[5]

LUC7L3
Identifiers
AliasesLUC7L3, CRA, CREAP-1, CROP, LUC7A, OA48-18, hLuc7A, LUC7 like 3 pre-mRNA splicing factor
External IDsOMIM: 609434 MGI: 1914934 HomoloGene: 75056 GeneCards: LUC7L3
Orthologs
SpeciesHumanMouse
Entrez

51747

67684

Ensembl

ENSG00000108848

ENSMUSG00000020863

UniProt

O95232

Q5SUF2

RefSeq (mRNA)

NM_006107
NM_016424
NM_001330330

NM_026313
NM_001361573
NM_001361574
NM_001361575

RefSeq (protein)

NP_001317259
NP_006098
NP_057508

NP_080589
NP_001348502
NP_001348503
NP_001348504

Location (UCSC)Chr 17: 50.72 – 50.76 MbChr 11: 94.18 – 94.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a cisplatin resistance-associated overexpressed protein (CROP). The N-terminal half of the CROP contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000108848 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020863 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CROP cisplatin resistance-associated overexpressed protein".

Further reading

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