LY6E

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene.[5][6][7] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues.[8] Ly6E is associated with drug resistance and tumor immune escape in breast cancer.[9] Further research is required to validate Ly6E for translation research.

LY6E
Identifiers
AliasesLY6E, RIG-E, RIGE, SCA-2, SCA2, TSA-1, lymphocyte antigen 6 complex, locus E, lymphocyte antigen 6 family member E
External IDsOMIM: 601384 MGI: 106651 HomoloGene: 56411 GeneCards: LY6E
Orthologs
SpeciesHumanMouse
Entrez

4061

17069

Ensembl

ENSG00000278032
ENSG00000160932

ENSMUSG00000022587

UniProt

Q16553

Q64253

RefSeq (mRNA)

NM_002346
NM_001127213

RefSeq (protein)

NP_001120685
NP_002337

Location (UCSC)Chr 8: 143.02 – 143.02 MbChr 15: 74.83 – 74.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. ENSG00000160932 GRCh38: Ensembl release 89: ENSG00000278032, ENSG00000160932 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022587 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Capone MC, Gorman DM, Ching EP, Zlotnik A (Sep 1996). "Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family". J Immunol. 157 (3): 969–73. PMID 8757598.
  6. Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Fu G, Yu L, Zhao SY, Waxman S, Lanotte M, Wang ZY, Tan JZ, Chan SJ, Chen Z (Jul 1996). "RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell". Proc Natl Acad Sci U S A. 93 (12): 5910–4. doi:10.1073/pnas.93.12.5910. PMC 39161. PMID 8650192.
  7. "Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E".
  8. Luo, Linlin; McGarvey, Peter; Madhavan, Subha; Kumar, Rakesh; Gusev, Yuriy; Upadhyay, Geeta (2016-02-03). "Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome". Oncotarget. 7 (10): 11165–93. doi:10.18632/oncotarget.7163. ISSN 1949-2553. PMC 4905465. PMID 26862846.
  9. Hossiny, Midrar A.; Luo, Linlin; Frazier, William R.; Steiner, Noriko; Gusev, Yuriy; Kallakury, Bhaskar; Glasgow, Eric; Creswell, Karen; Madhavan, Subha; Kumar, Rakesh; Upadhyay, Geeta (2016-04-11). "Ly6E/K signaling to TGF-β promotes breast cancer progression, immune escape and drug resistance". Cancer Research. 76 (11): 3376–3386. doi:10.1158/0008-5472.CAN-15-2654. ISSN 0008-5472. PMC 4910623. PMID 27197181.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.