LYAR

LYAR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WJV
Identifiers
Aliases	LYAR, ZC2HC2, ZLy1 antibody reactive
External IDs	OMIM: 617684 MGI: 107470 HomoloGene: 41200 GeneCards: LYAR
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	4,290,154 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	38,391,650 bp[2]
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sperm; ; monocyte; ; pericardium; ; lymph node; ; spleen; ; Achilles tendon; ; appendix; ; blood; ; gastrocnemius muscle;
	Top expressed in
	otic placode; ; spermatid; ; seminiferous tubule; ; spermatocyte; ; saccule; ; primitive streak; ; interventricular septum; ; yolk sac; ; Paneth cell; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; protein binding; RNA binding; DNA binding;
Cellular component	nucleus; nucleolus; photoreceptor outer segment; cytoplasm; cell projection;
Biological process	negative regulation of transcription by RNA polymerase II; rRNA processing; erythrocyte development; positive regulation of phagocytosis;
	Sources:Amigo / QuickGO
Orthologs
	55646
	17089
	ENSG00000145220
	ENSMUSG00000067367
	Q9NX58
	Q08288
	NM_001145725; NM_017816
	NM_025281
	NP_001139197; NP_060286
	NP_079557
	Wikidata
View/Edit Human	View/Edit Mouse

Cell growth-regulating nucleolar protein is a protein that in humans is encoded by the LYAR gene (Ly-1 antibody reactive clone).[5]

LYAR contains a zinc finger motif and three copies of nuclear localization signals. LYAR is mainly localized to the nucleoli. LYAR is present at high levels in early embryos and preferentially in the liver fetal thymus.[6]

References

GRCh38: Ensembl release 89: ENSG00000145220 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000067367 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: LYAR hypothetical protein FLJ20425".
Su L, Hershberger RJ, Weissman IL (May 1993). "LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation". Genes Dev. 7 (5): 735–48. doi:10.1101/gad.7.5.735. PMID 8491376.

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145220 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067367 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LYAR hypothetical protein FLJ20425".

[pmid8491376-6] Su L, Hershberger RJ, Weissman IL (May 1993). "LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation". Genes Dev. 7 (5): 735–48. doi:10.1101/gad.7.5.735. PMID 8491376.

LYAR

References

Further reading