LYPD1

LYPD1
Identifiers
Aliases	LYPD1, LYPDC1, PHTS, LY6/PLAUR domain containing 1
External IDs	OMIM: 610450 MGI: 1919835 HomoloGene: 16937 GeneCards: LYPD1
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	132,671,579 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	125,840,838 bp[2]
RNA expression pattern
	Top expressed in
	right uterine tube; ; nucleus accumbens; ; caudate nucleus; ; putamen; ; hypothalamus; ; amygdala; ; pituitary gland; ; cingulate gyrus; ; anterior pituitary; ; ganglionic eminence;
	Top expressed in
	cuneiform bones; ; cranial nervi; ; inferior ganglion of vagus nerve; ; amygdala; ; olfactory nerve; ; superior frontal gyrus; ; barrel cortex; ; Greater petrosal nerve; ; trigeminal nerve; ; caudate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	acetylcholine receptor binding; acetylcholine receptor inhibitor activity;
Cellular component	membrane; anchored component of membrane; extracellular region; plasma membrane;
Biological process	response to nicotine; behavioral fear response; negative regulation of signaling receptor activity; synaptic transmission, cholinergic; cell activation; acetylcholine receptor signaling pathway; negative regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	116372
	72585
	ENSG00000150551
	ENSMUSG00000026344
	Q8N2G4
	Q8BLC3
	NM_001077427; NM_144586; NM_001321234; NM_001321235
	NM_145100; NM_001311089; NM_001311090
	NP_001070895; NP_001308163; NP_001308164; NP_653187
	NP_001298018; NP_001298019; NP_659568
	Wikidata
View/Edit Human	View/Edit Mouse

Ly6/PLAUR domain-containing protein 1 is a protein that in humans is encoded by the LYPD1 gene.[5][6]

This protein is also known as Lynx2, a member of the Lynx family of neurotransmitter receptor-binding proteins.[7] Transgenic mice without Lynx2 expression have increased anxiety-related behaviors.[8]

References

GRCh38: Ensembl release 89: ENSG00000150551 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026344 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
"Entrez Gene: LYPD1 LY6/PLAUR domain containing 1".
Miwa, J. M.; Lester, H. A.; Walz, A. (2012). "Optimizing Cholinergic Tone Through Lynx Modulators of Nicotinic Receptors: Implications for Plasticity and Nicotine Addiction". Physiology. 27 (4): 187–199. doi:10.1152/physiol.00002.2012. PMID 22875450.
Tekinay, A. B.; Nong, Y.; Miwa, J. M.; Lieberam, I.; Ibanez-Tallon, I.; Greengard, P.; Heintz, N. (2009). "A role for LYNX2 in anxiety-related behavior". Proceedings of the National Academy of Sciences. 106 (11): 4477–4482. Bibcode:2009PNAS..106.4477T. doi:10.1073/pnas.0813109106. PMC 2657456. PMID 19246390.

Yu DH, Fan W, Liu G, et al. (2006). "PHTS, a novel putative tumor suppressor, is involved in the transformation reversion of HeLaHF cells independently of the p53 pathway". Exp. Cell Res. 312 (6): 865–76. doi:10.1016/j.yexcr.2005.12.006. PMID 16413018.
Choy KW, Wang CC, Ogura A, et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiol. Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150551 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026344 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gene: LYPD1 LY6/PLAUR domain containing 1".

[7] Miwa, J. M.; Lester, H. A.; Walz, A. (2012). "Optimizing Cholinergic Tone Through Lynx Modulators of Nicotinic Receptors: Implications for Plasticity and Nicotine Addiction". Physiology. 27 (4): 187–199. doi:10.1152/physiol.00002.2012. PMID 22875450.

[8] Tekinay, A. B.; Nong, Y.; Miwa, J. M.; Lieberam, I.; Ibanez-Tallon, I.; Greengard, P.; Heintz, N. (2009). "A role for LYNX2 in anxiety-related behavior". Proceedings of the National Academy of Sciences. 106 (11): 4477–4482. Bibcode:2009PNAS..106.4477T. doi:10.1073/pnas.0813109106. PMC 2657456. PMID 19246390.

LYPD1

References

Further reading