Lactate dehydrogenase b

Lactate dehydrogenase B is a protein that in humans is encoded by the LDHB gene. [5]

LDHB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLDHB, HEL-S-281, LDH-B, LDH-H, LDHBD, TRG-5, lactate dehydrogenase B
External IDsOMIM: 150100 MGI: 96763 HomoloGene: 55647 GeneCards: LDHB
Orthologs
SpeciesHumanMouse
Entrez

3945

16832

Ensembl

ENSG00000111716

ENSMUSG00000030246

UniProt

P07195

P16125

RefSeq (mRNA)

NM_001174097
NM_002300
NM_001315537

NM_008492
NM_001302765
NM_001316322

RefSeq (protein)

NP_001167568
NP_001302466
NP_002291

NP_001289694
NP_001303251
NP_032518

Location (UCSC)Chr 12: 21.64 – 21.76 MbChr 6: 142.44 – 142.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13.

References

  1. GRCh38: Ensembl release 89: ENSG00000111716 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030246 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Lactate dehydrogenase B". Retrieved 2017-10-01.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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