Lactoyl-CoA dehydratase

The enzyme lactoyl-CoA dehydratase (EC 4.2.1.54) catalyzes the chemical reaction

lactoyl-CoA acryloyl-CoA + H2O
lactoyl-CoA dehydratase
Identifiers
EC no.4.2.1.54
CAS no.9031-12-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is lactoyl-CoA hydro-lyase (acryloyl-CoA-forming). Other names in common use include lactoyl coenzyme A dehydratase, lactyl-coenzyme A dehydrase, lactyl CoA dehydratase, acrylyl coenzyme A hydratase, and lactoyl-CoA hydro-lyase. This enzyme participates in propanoate metabolism and styrene degradation.

References

    • BALDWIN RL, WOOD WA, EMERY RS (1965). "LACTATE METABOLISM BY PEPTOSTREPTOCOCCUS ELSDENII: EVIDENCE FOR LACTYL COENZYME A DEHYDRASE". Biochim. Biophys. Acta. 97: 202–13. doi:10.1016/0304-4165(65)90084-x. PMID 14292829.


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