Levopimaradiene synthase

Levopimaradiene synthase (EC 4.2.3.32, PtTPS-LAS, LPS, copalyl-diphosphate diphosphate-lyase [abieta-8(14),12-diene-forming]) is an enzyme with systematic name (+)-copalyl-diphosphate diphosphate-lyase (abieta-8(14),12-diene-forming).[1][2] This enzyme catalyses the following chemical reaction

(+)-copalyl diphosphate abieta-8(14),12-diene + diphosphate
Levopimaradiene synthase
Identifiers
EC no.4.2.3.32
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

In Ginkgo, the enzyme catalyses the initial cyclization step in the biosynthesis of ginkgolides.

References

  1. Schepmann HG, Pang J, Matsuda SP (August 2001). "Cloning and characterization of Ginkgo biloba levopimaradiene synthase which catalyzes the first committed step in ginkgolide biosynthesis". Archives of Biochemistry and Biophysics. 392 (2): 263–9. doi:10.1006/abbi.2001.2438. PMID 11488601.
  2. Ro DK, Bohlmann J (August 2006). "Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)". Phytochemistry. 67 (15): 1572–8. doi:10.1016/j.phytochem.2006.01.011. PMID 16497345.
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