Chlordiazepoxide/clidinium bromide

Chlordiazepoxide/clidinium bromide (marketed as Librax) is a fixed-dose combination medication used to treat peptic ulcers, irritable bowel syndrome (IBS), and gastritis.[1] It contains chlordiazepoxide and clidinium bromide. It helps relieve stomach spasms, abdominal cramps, and anxiety related to gastric disorders.[2] Librax is a fixed ratio of these two medications and, as such, is not typically prescribed with an accompanying dosage, but rather directions on how many capsules to take per day. It comes in a capsule taken by mouth, usually three or four times daily, before meals and at bedtime.[2] Chlordiazepoxide is an anti-anxiety medication belonging to the benzodiazepine class.[3] Its use in IBS is thought to be due to its calming ability for patients that have IBS symptoms that are worsened by anxiety. Clidinium bromide is a synthetic quaternary ammonium antimuscarinic,[4] a sub-class of a family of drugs known as anticholinergics. It treats IBS by decreasing gastrointestinal motility.

Chlordiazepoxide/clidinium bromide
Combination of
ChlordiazepoxideAnxiolytic
Clidinium bromideAntimuscarinic
Clinical data
Trade namesLibrax
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa601036
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
KEGG
CompTox Dashboard (EPA)
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Chlordiazepoxide can be habit-forming. Tolerance may develop with long-term or excessive use, making this medication less effective. This medication must be taken regularly to be effective. Stopping the drug suddenly can worsen the condition and cause withdrawal symptoms (anxiousness, sleeplessness, and irritability).[2]

It was approved for medical use in the United States in 1966.[5][6] It is available as a generic medication.[7]

Medical uses

Chlordiazepoxide/clidinium bromide is indicated to control emotional and somatic factors in gastrointestinal disorders.[6] It may also be used as adjunctive therapy in the treatment of peptic ulcer and in the treatment of the irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.[6]

References
  1. Donnelly P (2010). "Gasterointestinal Drugs". Nurse's Handbook of Combination Drugs (2nd ed.). Sudbury, Mass.: Jones and Bartlett Publishers. p. 537. ISBN 978-0-7637-6549-1.
  2. "Librax". MedlinePlus: US National library of medicine. Retrieved 31 May 2013.
  3. "Chlordiazepoxide". MedScape.
  4. "Clidinium". Drugs.com.
  5. "Librax: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 15 August 2020.
  6. "Librax- chlordiazepoxide hydrochloride and clidinium bromide capsule". DailyMed. 31 May 2020. Retrieved 15 August 2020.
  7. "Chlordiazepoxide hydrochloride and clidinium bromide: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 15 August 2020.


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