Lig RNA thermometer
Lig RNA thermometer is a cis-acting non-coding RNA element that controls ligA and ligB gene expression in Leptospira interrogans in response to temperature change.[1] The lipoproteins LigA and LigB stimulate adhesion of the element and then hosting proteins.[2] The RNA that composes of 175-nucleotide 5'UTR and the first six lig codons (identical in ligA and ligB) folds into two distinct-stem loop structures. Lig expression is limited by these double-stranded RNA structures because they occludes the ribosome-binding site. At higher temperatures, the ribosome binding site is exposed to promote translation initiation.[1]
| Lig RNA thermometer | |
|---|---|
 Predicted secondary structure and sequence conservation of Lig thermometer | |
| Identifiers | |
| Rfam | RF02815 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0009266 ,GO:0030371 |
| SO | SO:005836,SO:0000204 |
| PDB structures | PDBe |
References
- Matsunaga J, Schlax PJ, Haake DA (November 2013). "Role for cis-acting RNA sequences in the temperature-dependent expression of the multiadhesive lig proteins in Leptospira interrogans". Journal of Bacteriology. 195 (22): 5092–5101. doi:10.1128/JB.00663-13. PMC 3811586. PMID 24013626.
- Choy HA, Kelley MM, Chen TL, Møller AK, Matsunaga J, Haake DA (May 2007). "Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogen". Infection and Immunity. 75 (5): 2441–2450. doi:10.1128/IAI.01635-06. PMC 1865782. PMID 17296754.
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