Limbus sign

Limbus sign
Limbus sign
Differential diagnosis	increased calcium concentration in the blood

The limbus sign is a ring of dystrophic calcification evident as a "milky precipitate" (i.e. abnormal white color) at the corneal limbus. The corneal limbus is the part of the eye where the cornea (front/center) meets the sclera (white part of the eye). Thought to be caused by increased calcium concentration in the blood, this sign however persists after calcium phosphate concentration returns to normal.[1] Compare the limbus sign (calcification) with arcus senilis (lipid).[2]

References

Orient, Dr. Jane M. (2011). Amazon Sapira's Art & Science of Bedside Diagnosis (Kindle Edition) Lippincott Williams & Wilkins. Retrieved January 7, 2012.
Edwards, Mark E. (2008). Geriatric physical diagnosis: a guide to observation and assessment. McFarland & Company. p. 96. Retrieved January 7, 2012.

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[1] Orient, Dr. Jane M. (2011). Amazon Sapira's Art & Science of Bedside Diagnosis (Kindle Edition) Lippincott Williams & Wilkins. Retrieved January 7, 2012.

[2] Edwards, Mark E. (2008). Geriatric physical diagnosis: a guide to observation and assessment. McFarland & Company. p. 96. Retrieved January 7, 2012.