Liquid ordered phase

Regarding biological membranes, the liquid ordered phase is a liquid crystalline phase of a lipid bilayer, and is of significant biological importance. It occurs in many lipid mixtures combining cholesterol with a phospholipid and/or sphingolipids e.g. sphingomyelin. This phase has been related to lipid rafts that may exist in plasma membranes.

Definition

The liquid ordered phase can be defined as:


History

This was first called the liquid ordered phase by Ipsen et al. (1987). However, it has also been called the LGI subgel phase by Huang et al. (1993) and the β phase by Vist and Davis (1990).

References

  • Ipsen, J. H., G. Karlstrom, O. G. Mouritsen, H. Wennerstrom, and M. J. Zuckermann. 1987. Phase equilibria in the phosphatidylcholine-cholesterol system. Biochim. Biophys. Acta. 905:162–172.
  • Huang TH, Lee CWB, Dasgupta SK, Blume A, Griffin RG. 1993. "A C-13 and H-2 Nuclear-Magnetic-Resonance Study of Phosphatidylcholine Cholesterol Interactions - Characterization of Liquid-Gel Phases." Biochemistry 32(48):13277-13287
  • Vist MR, Davis JH. 1990. "Phase-Equilibria of Cholesterol Dipalmitoylphosphatidylcholine Mixtures - H-2 Nuclear Magnetic-Resonance and Differential Scanning Calorimetry." Biochemistry 29(2):451-464.
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