Long-chain-enoyl-CoA hydratase

The enzyme long-chain-enoyl-CoA hydratase (EC 4.2.1.74) catalyzes the chemical reaction

(3S)-3-hydroxyacyl-CoA trans-2-enoyl-CoA + H2O
long-chain-enoyl-CoA hydratase
Identifiers
EC no.4.2.1.74
CAS no.62009-81-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase. This enzyme is also called long-chain enoyl coenzyme A hydratase. This enzyme participates in fatty acid elongation in mitochondria and fatty acid metabolism.

References

    • Fong JC, Schulz H (1977). "Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratases in pig and guinea pig tissues". J. Biol. Chem. 252 (2): 542–7. PMID 833142.
    • Schulz H (1974). "Long chain enoyl coenzyme A hydratase from pig heart". J. Biol. Chem. 249 (9): 2704–9. PMID 4828315.


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