Louis Dubertret

Dubertret studied in Douai and Amiens before entering the Paris Faculty of Medicine. In 1965 he was an extern at the hospitals of Paris as well as a student of Maurice Tubiana in cancer research and of Fred Siguier, a specialist in internal medicine.

In May 1968, he served on a committee to reform medical studies. Some of the committee's recommendations were enacted into the Orientation Law, proposed by Edgar Faure in November 1968.

In 1970, Dubertret started his residency and discovered the importance of dermatological manifestations in internal medicine, thanks to professors Jean Hewitt and René Touraine. From 1972 to 1973, Dubertret was an assistant attaché in experimental pathology at the Paris Faculty of Medicine. He wrote his thesis on psoriasis physiopathology, finishing his residency in 1975.

In 1975, Dubertret suggested to Touraine that they set up a research laboratory in dermatology at Henri Mondor Hospital.[1] From 1975 to 1977, Dubertret was an associate clinical director and an assistant professor in fundamental science at the Creteil Faculty of Medicine.[2] In 1977, he became clinical director.

From 1976 to 1977, he created a degree in cutaneous physiology. In 1982, he became an associate professor of dermatology at Paris West, then at Paris VII.

From 1989 to 2009, Dubertret was the head of the Department of Dermatology at Saint-Louis Hospital, the national reference center for that specialty. From 1987 to 1989, Dubertret was also a member of the National Council of Universities, and in 1993 he became director of the national masters in biology and cutaneous pharmacology at the doctoral school B2T. He was also responsible for continuing medical education in dermatology at the Entretiens de Bichat from 1995 to 2005.

In September 2012, Dubertret's university functions ended and he became Professor Emeritus.

As senior consultant at Saint-Louis Hospital, Dubertret set up dedicated outpatient consultations to assemble specific expertise in each kind of disease. In his department, dermatology was subdivided into dedicated outpatient consultations:psoriasis, melanoma, rare genetic skin diseases, contact allergies, and photobiology.

In 1995, Dubertret formalized a new medical treatment of chronic diseases, composed of four steps: questioning, explanation, negotiation, and prescription, which allowed systematic universal care of patients.[3][4]

In 1993, with Edouard Couty and Pascal Reygagne, Dubretret created the Sabouraud Health Center[5] at the Saint-Louis Hospital in Paris. Dubertret is the president of this center, specializing in skin and hair.

Louis Dubertret and his team developed methods to study cutaneous inflammation in vitro and in vivo. First, they developed histology methods to study the new functions of inflammatory skin cells.[6] Then they optimized the technique of "suction bubbles" and "skin chambers". This technique allowed them to study in vivo human molecular and cellular events implicated in inflammatory reactions, particularly in psoriasis and in allergic reactions.[7][8]

This quantitative and dynamic approach to the in vivo inflammation in humans contributed to a better understanding of psoriasis. In therapeutic research, Dubertret coordinated several studies to evaluate anti-psoriatic drugs. In 2005, the René Touraine Foundation (fr: Fondation René Touraine), under the leadership of Dubertret, initiated—in collaboration with eleven European countries—the Psoriasis International Network, a network aimed to develop clinical and therapeutic research for psoriatic patients.[9]

In 1997, Raymond Latarjet entrusted Dubertret with the development of French research on drugs activated by light: psoralen. Dubertret coordinated the research activities of six fundamental research laboratories in photobiology to discover new photoactive molecules.[10]

He was also responsible for the Cooperative Research Program of CNRS on photoactive molecules and of the Department of Clinical Research of INSERM.

This work won the Galien Prize in 1989, the first time the award was given to a public laboratory.

Dubertret was also elected president of the French Society of Photobiology in 1987. That same year, he was named to the French Health Ministry as an expert in matters that concern the sun and skin.

With his team, Dubertret demonstrated that cellular behavior is different in vivo and in vitro. He reconstructed, in vitro, the cellular environment met in vivo. With Eugène Bell, from MIT, he developed the concept of organogenesis in vitro and developed a human skin model composed of dermis and epidermis with normal or pathologic cells.[11][12]

In 1983, thanks to this technique, the world's first transplants of entirely reconstructed human skin were performed on 16 patients with significant cutaneous malformations or burns.

This work was awarded the City of Paris Vermeil Medal, as well as the Claude-Bernard Grand Prize, which was presented in 1988 by Jacques Chirac, then the mayor of Paris.

In 1987, the laboratory became a research unit of INSERM.

Dubertret spent time from 1993 to 1996 developing the Skin Research Institute at the Saint-Louis Hospital with the help of public subsidies and private donations—particularly from Chanel and l’Oréal. He went on to head this institute until 2009.

As a public/private collaboration within the Saint-Louis Hospital, this bioclinical research laboratory worked with research teams from l’Oreal to better understand healthy skin reactions to environmental stresses and strains, and, in particular, the molecular process of skin aging. In 2008, this laboratory became the L’Oreal Research Center.