Luca Scorrano

Luca Scorrano is an Italian biologist and professor of Biochemistry at the University of Padua as well as the former Scientific Director of the Veneto Institute of Molecular Medicine in Italy.[1] He is known for his important contributions to the field of mitochondrial dynamics and the interface between mitochondria and the endoplasmic reticulum.

Luca Scorrano
Born6 September 1971
Italy
CitizenshipItalian
Alma materUniversity of Padova
Scientific career
InstitutionsUniversity of Padova

Veneto Institute of Molecular Medicine

University of Geneva
Academic advisorsStanley J. Korsmeyer

Biography and research

Scorrano obtained his M.D. and Ph.D. from the University of Padua Medical School in 1996 and 2001, respectively. He then moved to Boston where he worked with Stanley J. Korsmeyer at Harvard Medical School. It is during his postdoctoral work in Korsmeyer's lab that Luca became passionate about mitochondrial dynamics and discovered that mitochondrial cristae remodeling was involved in cytochrome c release and apoptosis.[2] In 2003 he returned to Italy to establish his lab at the University of Padua, and then in Geneva (Switzerland) where he was Professor at the Dept. of Cell Physiology and Metabolism. In 2013 he returned to his native Italy where he continued to unravel the molecular mechanisms of mitochondrial dynamics and their pathophysiological consequences.

He has been prolific in his contributions to the fields of apoptosis and mitochondrial pathophysiology,[3][4][5] as well as mitochondrial dynamics and interorganellar contact sites. His lab identified the role of Opa1, optic atrophy protein 1, in holding mitochondrial cristae junctions tight,[6][7] which is an important determinant of mitochondrial respiratory efficiency.[8] His lab also found augmentation of Opa1 to correct mitochondrial diseases and blunt muscular atrophy,[9] stroke and heart ischemia.[10] In 2008, Scorrano's lab identified Mfn2, a protein mutated in a peripheral neuropathy, as the first molecular bridge between endoplasmic reticulum and mitochondria.[11] His notable work contributed to the current understanding of how mitochondrial shape and structure influence cellular processes and cellular homeostasis.[12][13]

His lab is now focused on understanding the molecular mechanisms and pathophysiological consequences of mitochondrial dynamics and contacts with the ER in health and disease.

Awards

Scorrano received several prizes and awards, including the Eppendorf European Young Investigator, the Chiara D’Onofrio and the ESCI Award. He is an EMBO Member and sits in several Committees, Advisory and Editorial Boards.

References
  1. "Luca Scorrano". Google Scholar. Retrieved 9 December 2013.
  2. Scorrano, Luca; Ashiya, Mona; Buttle, Karolyn; Weiler, Solly; Oakes, Scott A.; Mannella, Carmen A.; Korsmeyer, Stanley J. (January 2002). "A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis". Developmental Cell. 2 (1): 55–67. doi:10.1016/s1534-5807(01)00116-2. ISSN 1534-5807. PMID 11782314.
  3. Cipolat, Sara; Rudka, Tomasz; Hartmann, Dieter; Costa, Veronica; Serneels, Lutgarde; Craessaerts, Katleen; Metzger, Kristine; Frezza, Christian; Annaert, Wim; D'Adamio, Luciano; Derks, Carmen (14 July 2006). "Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling". Cell. 126 (1): 163–175. doi:10.1016/j.cell.2006.06.021. ISSN 0092-8674. PMID 16839884. S2CID 6396519.
  4. Scorrano, Luca; Ashiya, Mona; Buttle, Karolyn; Weiler, Solly; Oakes, Scott A.; Mannella, Carmen A.; Korsmeyer, Stanley J. (January 2002). "A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis". Developmental Cell. 2 (1): 55–67. doi:10.1016/s1534-5807(01)00116-2. ISSN 1534-5807. PMID 11782314.
  5. Frezza, Christian; Cipolat, Sara; Martins de Brito, Olga; Micaroni, Massimo; Beznoussenko, Galina V.; Rudka, Tomasz; Bartoli, Davide; Polishuck, Roman S.; Danial, Nika N.; De Strooper, Bart; Scorrano, Luca (14 July 2006). "OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion". Cell. 126 (1): 177–189. doi:10.1016/j.cell.2006.06.025. ISSN 0092-8674. PMID 16839885. S2CID 11569831.
  6. Cipolat, Sara; Martins de Brito, Olga; Dal Zilio, Barbara; Scorrano, Luca (9 November 2004). "OPA1 requires mitofusin 1 to promote mitochondrial fusion". Proceedings of the National Academy of Sciences of the United States of America. 101 (45): 15927–15932. doi:10.1073/pnas.0407043101. ISSN 0027-8424. PMC 528769. PMID 15509649.
  7. Frezza, Christian; Cipolat, Sara; Martins de Brito, Olga; Micaroni, Massimo; Beznoussenko, Galina V.; Rudka, Tomasz; Bartoli, Davide; Polishuck, Roman S.; Danial, Nika N.; De Strooper, Bart; Scorrano, Luca (14 July 2006). "OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion". Cell. 126 (1): 177–189. doi:10.1016/j.cell.2006.06.025. ISSN 0092-8674. PMID 16839885. S2CID 11569831.
  8. Cogliati, Sara; Frezza, Christian; Soriano, Maria Eugenia; Varanita, Tatiana; Quintana-Cabrera, Ruben; Corrado, Mauro; Cipolat, Sara; Costa, Veronica; Casarin, Alberto; Gomes, Ligia C.; Perales-Clemente, Ester (26 September 2013). "Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency". Cell. 155 (1): 160–171. doi:10.1016/j.cell.2013.08.032. ISSN 1097-4172. PMC 3790458. PMID 24055366.
  9. Civiletto, Gabriele; Varanita, Tatiana; Cerutti, Raffaele; Gorletta, Tatiana; Barbaro, Serena; Marchet, Silvia; Lamperti, Costanza; Viscomi, Carlo; Scorrano, Luca; Zeviani, Massimo (2 June 2015). "Opa1 overexpression ameliorates the phenotype of two mitochondrial disease mouse models". Cell Metabolism. 21 (6): 845–854. doi:10.1016/j.cmet.2015.04.016. ISSN 1932-7420. PMC 4457891. PMID 26039449.
  10. Varanita, Tatiana; Soriano, Maria Eugenia; Romanello, Vanina; Zaglia, Tania; Quintana-Cabrera, Rubén; Semenzato, Martina; Menabò, Roberta; Costa, Veronica; Civiletto, Gabriele; Pesce, Paola; Viscomi, Carlo (2 June 2015). "The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage". Cell Metabolism. 21 (6): 834–844. doi:10.1016/j.cmet.2015.05.007. ISSN 1932-7420. PMC 4457892. PMID 26039448.
  11. Frezza, Christian; Cipolat, Sara; Martins de Brito, Olga; Micaroni, Massimo; Beznoussenko, Galina V.; Rudka, Tomasz; Bartoli, Davide; Polishuck, Roman S.; Danial, Nika N.; De Strooper, Bart; Scorrano, Luca (14 July 2006). "OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion". Cell. 126 (1): 177–189. doi:10.1016/j.cell.2006.06.025. ISSN 0092-8674. PMID 16839885. S2CID 11569831.
  12. Gomes, Ligia C.; Di Benedetto, Giulietta; Scorrano, Luca (May 2011). "During autophagy mitochondria elongate, are spared from degradation and sustain cell viability". Nature Cell Biology. 13 (5): 589–598. doi:10.1038/ncb2220. ISSN 1476-4679. PMC 3088644. PMID 21478857.
  13. Kasahara, Atsuko; Cipolat, Sara; Chen, Yun; Dorn, Gerald W.; Scorrano, Luca (8 November 2013). "Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling". Science. 342 (6159): 734–737. doi:10.1126/science.1241359. ISSN 1095-9203. PMID 24091702. S2CID 20355613.
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