Lumbrokinase

Lumbrokinase is a class of fibrinolytic enzymes[1][2] present in earthworm species including Lumbricus bimastus[3] and Lumbricus rubellus.[2]

This enzyme was first discovered in 1991 in earthworm saliva.[2] It is a clinically approved and proven antithrombotic agent in Asia.[4]

References
  1. Hu, R. (2004). "Codon optimization, expression, and characterization of recombinant lumbrokinase in goat milk". Protein Expression and Purification. 37 (1): 83–8. doi:10.1016/j.pep.2004.05.018. PMID 15294284.
  2. Mihara, Hisashi; Sumi, Hiroyuki; Yoneta, Tomoyuki; Mizumoto, Hideaki; Ikeda, Ryuzo; Seiki, Masao; Maruyama, Masugi (1991). "A novel fibrinolytic enzyme extracted from the earthworm, Lumbricus rubellus". The Japanese Journal of Physiology. 41 (3): 461–472. doi:10.2170/jjphysiol.41.461. PMID 1960890.
  3. Ge, T.; Sun, Z.; Fu, S.; Liang, G. (2005). "Cloning of thrombolytic enzyme (lumbrokinase) from earthworm and its expression in the yeast". Protein Expression and Purification. 42 (1): 20–8. doi:10.1016/j.pep.2005.04.005. PMID 15927482.
  4. Kasim, M.; Kiat, A. A.; Rohman, M. S.; Hanifah, Y.; Kiat, H. (2009). "Improved Myocardial Perfusion in Stable Angina Pectoris by Oral Lumbrokinase: A Pilot Study". The Journal of Alternative and Complementary Medicine. 15 (5): 539–44. doi:10.1089/acm.2008.0506. PMID 19416019.


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