Lynette Cegelski

Lynette Cegelski is an American physical chemist and chemical biologist who studies extracellular structures such as biofilms and membrane proteins. She is an associate professor of chemistry and, by courtesy, of chemical engineering at Stanford University.[1] She is a Stanford Bio-X and Stanford ChEM-H affiliated faculty member.[2][3]

Lynette Cegelski
NationalityAmerican
Alma materSUNY Binghamton
Washington University in St. Louis
Known forBacterial cell wall
Biofilms
AwardsPECASE
Burroughs Wellcome Career Award at the Scientific Interface
NIH Director's New Innovator Award
NSF CAREER Award
Scientific career
FieldsPhysical Chemistry
Chemical Biology
Websitehttps://www.cegelskilab.com/

Education

Cegelski studied chemistry at SUNY Binghamton in New York and graduated summa cum laude and a member of Phi Beta Kappa in 1998.[2][4] She then worked in the lab of Jacob Schaefer at Washington University in St. Louis (WUSTL), earning a PhD in Biophysical Chemistry in 2004.[1][5][6] Her post-doctoral work was in Molecular Microbiology at the Washington University School of Medicine.[1]

Research

The Cegelski Lab investigates the structure and function of bacterial cell walls and extracellular structures, including amyloid fibers and biofilms.[1]

Key Publications

Cegelski has authored or co-authored multiple publications that have been cited 100 or more times. As of January 2021, these include:

Awards

Cegelski's work has earned her several awards:

  • Presidential Early Career Award for Scientists and Engineers (PECASE)[14]
  • Burroughs Wellcome Career Award at the Scientific Interface, for "Mapping the structural and functional landscape of the microbial extracellular matrix."[15]
  • 2010 NIH Director's New Innovator Award, for "Structure, Function, and Disruption of Microbial Amyloid Assembly and Biofilm Formation."[16]
  • National Science Foundation CAREER Award, for "Form and Function of Bacterial Amyloid Fibers."[17]

References
  1. "Lynette Cegelski | Department of Chemistry". chemistry.stanford.edu. Retrieved 2021-01-24.
  2. University, © Stanford; Stanford; California 94305 (2014-03-12). "Lynette Cegelski - Associate Professor of Chemistry". Welcome to Bio-X. Retrieved 2021-01-24.
  3. "Lynette Cegelski | ChEM-H". chemh.stanford.edu. Retrieved 2021-01-24.
  4. "PHI BETA KAPPA QUALIFIED LIST 1997". people.math.binghamton.edu. Retrieved 2021-01-24.
  5. "Chemistry Tree - Lynette S. Cegelski". academictree.org. Retrieved 2021-01-24.
  6. "Past Graduate Students | Jacob Schaefer Research Group | Washington University in St. Louis". sites.wustl.edu. Retrieved 2021-01-24.
  7. Cegelski, Lynette; Marshall, Garland R.; Eldridge, Gary R.; Hultgren, Scott J. (Nov 2009). "Erratum: The biology and future prospects of antivirulence therapies". Nature Reviews Microbiology. 7 (11): 836. doi:10.1038/nrmicro2244. ISSN 1740-1526.
  8. Justice, Sheryl S.; Hunstad, David A.; Cegelski, Lynette; Hultgren, Scott J. (Feb 2008). "Morphological plasticity as a bacterial survival strategy". Nature Reviews Microbiology. 6 (2): 162–168. doi:10.1038/nrmicro1820. ISSN 1740-1526. PMID 18157153. S2CID 7247384.
  9. Cegelski, Lynette; Pinkner, Jerome S; Hammer, Neal D; Cusumano, Corinne K; Hung, Chia S; Chorell, Erik; Åberg, Veronica; Walker, Jennifer N; Seed, Patrick C; Almqvist, Fredrik; Chapman, Matthew R (2009-10-25). "Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation". Nature Chemical Biology. 5 (12): 913–919. doi:10.1038/nchembio.242. ISSN 1552-4450. PMC 2838449. PMID 19915538.
  10. Li, Yankun; Poliks, Barbara; Cegelski, Lynette; Poliks, Mark; Gryczynski, Zygmunt; Piszczek, Grzegorz; Jagtap, Prakash G.; Studelska, Daniel R.; Kingston, David G. I.; Schaefer, Jacob; Bane, Susan (Jan 2000). "Conformation of Microtubule-Bound Paclitaxel Determined by Fluorescence Spectroscopy and REDOR NMR †". Biochemistry. 39 (2): 281–291. doi:10.1021/bi991936r. ISSN 0006-2960. PMID 10630987.
  11. Kim, Sung Joon; Cegelski, Lynette; Stueber, Dirk; Singh, Manmilan; Dietrich, Evelyne; Tanaka, Kelly S.E.; Parr, Thomas R.; Far, Adel Rafai; Schaefer, Jacob (Mar 2008). "Oritavancin Exhibits Dual Mode of Action to Inhibit Cell-Wall Biosynthesis in Staphylococcus aureus". Journal of Molecular Biology. 377 (1): 281–293. doi:10.1016/j.jmb.2008.01.031. ISSN 0022-2836. PMC 2276640. PMID 18258256.
  12. Chen, Zhixing; Mercer, Jaron A. M.; Zhu, Xiaolei; Romaniuk, Joseph A. H.; Pfattner, Raphael; Cegelski, Lynette; Martinez, Todd J.; Burns, Noah Z.; Xia, Yan (2017-08-04). "Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene". Science. 357 (6350): 475–479. doi:10.1126/science.aan2797. ISSN 0036-8075. PMID 28774923.
  13. Thongsomboon, Wiriya; Serra, Diego O.; Possling, Alexandra; Hadjineophytou, Chris; Hengge, Regine; Cegelski, Lynette (2018-01-19). "Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose". Science. 359 (6373): 334–338. doi:10.1126/science.aao4096. ISSN 0036-8075. PMID 29348238.
  14. "Twelve from Stanford honored with the Presidential Early Career Award for Scientists and Engineers | Department of Chemistry". chemistry.stanford.edu. 5 July 2019. Retrieved 2021-01-24.
  15. "2012 Annual Report" (PDF). Burroughs Wellcome Fund. Retrieved 2021-01-24.
  16. "NIH Director's New Innovator Award - Funded Research". commonfund.nih.gov. 26 June 2013. Retrieved 2021-01-24.
  17. "NSF Award Search: Award#1453247 - CAREER: Form and Function of Bacterial Amyloid Fibers". www.nsf.gov. Retrieved 2021-01-24.
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