MADD (gene)

MADD
Identifiers
Aliases	MADD, DENN, IG20, RAB3GEP, MAP kinase activating death domain
External IDs	OMIM: 603584 MGI: 2444672 HomoloGene: 14249 GeneCards: MADD
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	47,330,031 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	91,183,837 bp[2]
RNA expression pattern
	Top expressed in
	anterior pituitary; ; Brodmann area 9; ; prefrontal cortex; ; cingulate gyrus; ; ganglionic eminence; ; nucleus accumbens; ; amygdala; ; orbitofrontal cortex; ; hypothalamus; ; hippocampus proper;
	Top expressed in
	superior frontal gyrus; ; cerebellar cortex; ; supraoptic nucleus; ; Region I of hippocampus proper; ; medial dorsal nucleus; ; cerebellar vermis; ; primary motor cortex; ; trigeminal ganglion; ; piriform cortex; ; cingulate gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	death receptor binding; guanyl-nucleotide exchange factor activity; protein kinase activator activity; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; cytoplasm; cytosol;
Biological process	regulation of apoptotic process; regulation of extrinsic apoptotic signaling pathway; execution phase of apoptosis; regulation of tumor necrosis factor-mediated signaling pathway; regulation of Rab protein signal transduction; regulation of cell cycle; cell surface receptor signaling pathway; regulation of extrinsic apoptotic signaling pathway via death domain receptors; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	8567
	228355
	ENSG00000110514
	ENSMUSG00000040687
	Q8WXG6
	Q80U28
NM_001135943; NM_001135944; NM_003682; NM_130470; NM_130471;
	NM_130472; NM_130473; NM_130474; NM_130475; NM_130476
NM_001177719; NM_001177720; NM_001177721; NM_001177722; NM_001177723;
	NM_001177724; NM_001177725; NM_001177726; NM_001177727; NM_001177728; NM_001177729; NM_145527
NP_001129415; NP_001129416; NP_003673; NP_569826; NP_569827;
	NP_569828; NP_569829; NP_569830; NP_569831; NP_569832; NP_001363500; NP_001363501; NP_001363502; NP_001363503; NP_001363504; NP_001363505; NP_001363506; NP_001363507; NP_001363508; NP_001363509; NP_001363510; NP_001363511; NP_001363512; NP_001363513; NP_001363514; NP_001363515; NP_001363522; NP_001363523; NP_001363524; NP_001363525; NP_001363526; NP_001363527; NP_001363528; NP_001363529; NP_001363530; NP_001363531; NP_001363532; NP_001363533; NP_001363534; NP_001363535; NP_001363536; NP_001363537; NP_001363538; NP_001363539; NP_001363540; NP_001363541; NP_001363542; NP_001363543; NP_001363544; NP_001363545; NP_001363546; NP_001363547; NP_001363548; NP_001363549; NP_001363550; NP_001363551; NP_001363552; NP_001363553; NP_001363554; NP_001363555; NP_001363556; NP_001363557; NP_001363558; NP_001363559; NP_001363560; NP_001363561; NP_001363562; NP_001363563; NP_001363564; NP_001363565; NP_001363566; NP_001363567; NP_001363568; NP_001363569; NP_001363570; NP_001363571; NP_001363572; NP_001363573; NP_001363574; NP_001363575; NP_001363576; NP_001363577; NP_001363578; NP_001363579; NP_001363580; NP_001363581; NP_001363582; NP_001363583; NP_001363584; NP_001363585; NP_001363586; NP_001363587; NP_001363588; NP_001363589; NP_001363590; NP_001363591; NP_001363592
	NP_001171190; NP_001171191; NP_663502
	Wikidata
View/Edit Human	View/Edit Mouse

MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene.[5][6][7]

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.[7]

References

GRCh38: Ensembl release 89: ENSG00000110514 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040687 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Schievella AR, Chen JH, Graham JR, Lin LL (Jun 1997). "MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase". J Biol Chem. 272 (18): 12069–75. doi:10.1074/jbc.272.18.12069. PMID 9115275.
Chow VT, Lim KM, Lim D (Nov 1998). "The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22". Genome. 41 (4): 543–52. doi:10.1139/gen-41-4-543. PMID 9796103.
"Entrez Gene: MADD MAP-kinase activating death domain".

Chow VT, Lee SS (1997). "DENN, a novel human gene differentially expressed in normal and neoplastic cells". DNA Seq. 6 (5): 263–73. doi:10.3109/10425179609020873. PMID 8988362.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
Zhang Y, Zhou L, Miller CA (1998). "A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2586–91. Bibcode:1998PNAS...95.2586Z. doi:10.1073/pnas.95.5.2586. PMC 19423. PMID 9482930.
Suzuki Y, Ishihara D, Sasaki M, et al. (2000). "Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries". Genomics. 64 (3): 286–97. doi:10.1006/geno.2000.6076. PMID 10756096.
Telliez JB, Bean KM, Lin LL (2000). "LRDD, a novel leucine rich repeat and death domain containing protein". Biochim. Biophys. Acta. 1478 (2): 280–8. doi:10.1016/S0167-4838(00)00029-7. PMID 10825539.
Iwasaki K, Toyonaga R (2000). "The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission". EMBO J. 19 (17): 4806–16. doi:10.1093/emboj/19.17.4806. PMC 302062. PMID 10970871.
Al-Zoubi AM, Efimova EV, Kaithamana S, et al. (2002). "Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3". J. Biol. Chem. 276 (50): 47202–11. doi:10.1074/jbc.M104835200. PMID 11577081.
Lim KM, Chow VT (2002). "Induction of marked apoptosis in mammalian cancer cell lines by antisense DNA treatment to abolish expression of DENN (differentially expressed in normal and neoplastic cells)". Mol. Carcinog. 35 (3): 110–26. doi:10.1002/mc.10082. PMID 12410563. S2CID 21107199.
Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Efimova E, Martinez O, Lokshin A, et al. (2004). "IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth". Cancer Res. 63 (24): 8768–76. PMID 14695193.
Efimova EV, Al-Zoubi AM, Martinez O, et al. (2004). "IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs". Oncogene. 23 (5): 1076–87. doi:10.1038/sj.onc.1207210. PMID 14716293.
Lim KM, Yeo WS, Chow VT (2004). "Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle". Int. J. Cancer. 109 (1): 24–37. doi:10.1002/ijc.11660. PMID 14735464. S2CID 10327890.
Del Villar K, Miller CA (2004). "Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons". Proc. Natl. Acad. Sci. U.S.A. 101 (12): 4210–5. Bibcode:2004PNAS..101.4210D. doi:10.1073/pnas.0307349101. PMC 384720. PMID 15007167.
Xu Y, Kulkosky J, Acheampong E, et al. (2004). "HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 7070–5. Bibcode:2004PNAS..101.7070X. doi:10.1073/pnas.0304859101. PMC 406467. PMID 15103018.
Ramaswamy M, Efimova EV, Martinez O, et al. (2005). "IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC". Oncogene. 23 (36): 6083–94. doi:10.1038/sj.onc.1207804. PMID 15208670.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hu YF, Zhang HL, Cai T, et al. (2006). "The IA-2 interactome" (PDF). Diabetologia. 48 (12): 2576–81. doi:10.1007/s00125-005-0037-y. PMID 16273344. S2CID 9765497.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110514 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040687 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9115275-5] Schievella AR, Chen JH, Graham JR, Lin LL (Jun 1997). "MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase". J Biol Chem. 272 (18): 12069–75. doi:10.1074/jbc.272.18.12069. PMID 9115275.

[pmid9796103-6] Chow VT, Lim KM, Lim D (Nov 1998). "The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22". Genome. 41 (4): 543–52. doi:10.1139/gen-41-4-543. PMID 9796103.

[entrez-7] "Entrez Gene: MADD MAP-kinase activating death domain".

MADD (gene)

References

Further reading