MAF1

Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene.[5][6][7]

MAF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAF1, MAF1 homolog, negative regulator of RNA polymerase III
External IDsOMIM: 610210 MGI: 1916127 HomoloGene: 49867 GeneCards: MAF1
Orthologs
SpeciesHumanMouse
Entrez

84232

68877

Ensembl

ENSG00000179632

ENSMUSG00000022553

UniProt

Q9H063

Q9D0U6

RefSeq (mRNA)

NM_032272

NM_001164607
NM_001164608
NM_026859

RefSeq (protein)

NP_115648

NP_001158079
NP_001158080
NP_081135

Location (UCSC)Chr 8: 144.1 – 144.11 MbChr 15: 76.24 – 76.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that is homologous to Maf1, a Saccharomyces cerevisiae protein which is highly conserved in eukaryotic cells. S. cerevisiae Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses Pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000179632 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022553 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. Pluta K, Lefebvre O, Martin NC, Smagowicz WJ, Stanford DR, Ellis SR, Hopper AK, Sentenac A, Boguta M (Jul 2001). "Maf1p, a Negative Effector of RNA Polymerase III in Saccharomyces cerevisiae". Mol Cell Biol. 21 (15): 5031–40. doi:10.1128/MCB.21.15.5031-5040.2001. PMC 87229. PMID 11438659.
  7. "Entrez Gene: MAF1 MAF1 homolog (S. cerevisiae)".

Further reading


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