MAGEB2

Melanoma-associated antigen B2 is a protein that in humans is encoded by the MAGEB2 gene.[5][6]

MAGEB2
Identifiers
AliasesMAGEB2, CT3.2, DAM6, MAGE-XP-2, MAGE family member B2
External IDsOMIM: 300098 MGI: 2148568 HomoloGene: 134515 GeneCards: MAGEB2
Orthologs
SpeciesHumanMouse
Entrez

4113

434903

Ensembl

ENSG00000099399

ENSMUSG00000035427

UniProt

O15479

A2A9R3

RefSeq (mRNA)

NM_002364

NM_001033492

RefSeq (protein)

NP_002355

NP_001028664

Location (UCSC)Chr X: 30.22 – 30.22 MbChr X: 85.29 – 85.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000099399 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035427 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lurquin C, De Smet C, Brasseur F, Muscatelli F, Martelange V, De Plaen E, Brasseur R, Monaco AP, Boon T (Mar 1998). "Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins". Genomics. 46 (3): 397–408. doi:10.1006/geno.1997.5052. PMID 9441743.
  6. "Entrez Gene: MAGEB2 melanoma antigen family B, 2".

Further reading


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