MAGI2

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2 gene.[5][6][7]

MAGI2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAGI2, ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM, membrane associated guanylate kinase, WW and PDZ domain containing 2, NPHS15
External IDsOMIM: 606382 MGI: 1354953 HomoloGene: 8189 GeneCards: MAGI2
Orthologs
SpeciesHumanMouse
Entrez

9863

50791

Ensembl

ENSG00000187391

ENSMUSG00000040003

UniProt

Q86UL8

Q9WVQ1

RefSeq (mRNA)

NM_001301128
NM_012301

NM_001170745
NM_001170746
NM_015823

RefSeq (protein)

NP_001288057
NP_036433

NP_001164216
NP_001164217
NP_056638

Location (UCSC)Chr 7: 78.02 – 79.45 MbChr 5: 19.43 – 20.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral-pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.[7]

Interactions

MAGI2 has been shown to interact with ATN1[8] and PTEN (gene).

References

  1. GRCh38: Ensembl release 89: ENSG00000187391 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040003 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shoji H, Tsuchida K, Kishi H, Yamakawa N, Matsuzaki T, Liu Z, Nakamura T, Sugino H (Mar 2000). "Identification and characterization of a PDZ protein that interacts with activin type II receptors". J Biol Chem. 275 (8): 5485–92. doi:10.1074/jbc.275.8.5485. PMID 10681527.
  6. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  7. "Entrez Gene: MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2".
  8. Wood, J D; Yuan J; Margolis R L; Colomer V; Duan K; Kushi J; Kaminsky Z; Kleiderlein J J; Sharp A H; Ross C A (Jun 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol. Cell. Neurosci. United States. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. ISSN 1044-7431. PMID 9647693. S2CID 20003277.

Further reading


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