MAGOH

Protein mago nashi homolog is a protein that in humans is encoded by the MAGOH gene.[5][6]

MAGOH
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAGOH, MAGOH1, MAGOHA, mago homolog, exon junction complex core component, mago homolog, exon junction complex subunit
External IDsOMIM: 602603 MGI: 1330312 HomoloGene: 1776 GeneCards: MAGOH
Orthologs
SpeciesHumanMouse
Entrez

4116

17149

Ensembl

ENSG00000162385

ENSMUSG00000028609

UniProt

P61326

P61327

RefSeq (mRNA)

NM_002370

NM_001282737

RefSeq (protein)

NP_002361

NP_001269666

Location (UCSC)Chr 1: 53.23 – 53.24 MbChr 4: 107.74 – 107.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.[6]

Interactions

MAGOH has been shown to interact with RBM8A[7][8] and NXF1.[8] In Drosophila melanogaster, Mago Nashi and Tsunagi/Y14 (core components of the exon junction complex) form a complex with a novel zinc finger protein, Ranshi, that has a role in oocyte differentiation.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000162385 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028609 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhao XF, Colaizzo-Anas T, Nowak NJ, Shows TB, Elliott RW, Aplan PD (April 1998). "The mammalian homologue of mago nashi encodes a serum-inducible protein". Genomics. 47 (2): 319–22. doi:10.1006/geno.1997.5126. PMID 9479507.
  6. "Entrez Gene: MAGOH mago-nashi homolog, proliferation-associated (Drosophila)".
  7. Zhao, X F; Nowak N J; Shows T B; Aplan P D (January 2000). "MAGOH interacts with a novel RNA-binding protein". Genomics. UNITED STATES. 63 (1): 145–8. doi:10.1006/geno.1999.6064. ISSN 0888-7543. PMID 10662555.
  8. Kataoka, N; Diem M D; Kim V N; Yong J; Dreyfuss G (November 2001). "Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex". EMBO J. England. 20 (22): 6424–33. doi:10.1093/emboj/20.22.6424. ISSN 0261-4189. PMC 125744. PMID 11707413.
  9. Lewandowski JP, Sheehan KB, Bennett PE Jr, Boswell RE (Mar 2010). "Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogaster". Dev. Biol. 339 (2): 307–19. doi:10.1016/j.ydbio.2009.12.035. PMC 2852135. PMID 20045686.

Further reading

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