MAN1A1

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA is an enzyme that in humans is encoded by the MAN1A1 gene.[5][6]

MAN1A1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAN1A1, HUMM3, HUMM9, MAN9, mannosidase alpha class 1A member 1
External IDsOMIM: 604344 MGI: 104677 HomoloGene: 4316 GeneCards: MAN1A1
Orthologs
SpeciesHumanMouse
Entrez

4121

17155

Ensembl

ENSG00000111885

ENSMUSG00000003746

UniProt

P33908

P45700

RefSeq (mRNA)

NM_005907

NM_008548

RefSeq (protein)

NP_005898

NP_032574

Location (UCSC)Chr 6: 119.18 – 119.35 MbChr 10: 53.78 – 53.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the removal of 3 distinct mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000111885 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003746 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bause E, Bieberich E, Rolfs A, Volker C, Schmidt B (Dec 1993). "Molecular cloning and primary structure of Man9-mannosidase from human kidney". Eur J Biochem. 217 (2): 535–40. doi:10.1111/j.1432-1033.1993.tb18274.x. PMID 8223597.
  6. "Entrez Gene: MAN1A1 mannosidase, alpha, class 1A, member 1".

Further reading


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