MAP4K5

MAP4K5
Identifiers
Aliases	MAP4K5, GCKR, KHS, KHS1, MAPKKKK5, mitogen-activated protein kinase kinase kinase kinase 5
External IDs	OMIM: 604923 MGI: 1925503 HomoloGene: 38199 GeneCards: MAP4K5
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	50,561,126 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	69,939,974 bp[2]
RNA expression pattern
	Top expressed in
	corpus callosum; ; sural nerve; ; Achilles tendon; ; tibia; ; canal of the cervix; ; germinal epithelium; ; skin of abdomen; ; inferior ganglion of vagus nerve; ; myometrium; ; subthalamic nucleus;
	Top expressed in
	secondary oocyte; ; interventricular septum; ; atrium; ; dermis; ; maxillary prominence; ; atrioventricular valve; ; pineal gland; ; belly cord; ; spermatid; ; cerebellar vermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; protein serine/threonine kinase activity; nucleotide binding; protein binding; ATP binding; kinase activity; MAP kinase kinase kinase kinase activity;
Cellular component	cytoplasm;
Biological process	protein phosphorylation; intracellular signal transduction; phosphorylation; regulation of mitotic cell cycle; regulation of apoptotic process; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	11183
	399510
	ENSG00000012983
	ENSMUSG00000034761
	Q9Y4K4
	Q8BPM2
	NM_006575; NM_198794
	NM_201519
	NP_006566; NP_942089
	NP_958927
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase kinase 5 is an enzyme that in humans is encoded by the MAP4K5 gene.[5][6][7]

This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[7]

Interactions

MAP4K5 has been shown to interact with CRKL[8] and TRAF2.[9]

References

GRCh38: Ensembl release 89: ENSG00000012983 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034761 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Tung RM, Blenis J (March 1997). "A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase". Oncogene. 14 (6): 653–9. doi:10.1038/sj.onc.1200877. PMID 9038372.
Schultz SJ, Nigg EA (February 1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
"Entrez Gene: MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5".
Shi, C S; Tuscano J; Kehrl J H (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation". Blood. UNITED STATES. 95 (3): 776–82. doi:10.1182/blood.V95.3.776.003k23_776_782. ISSN 0006-4971. PMID 10648385. S2CID 22593342.
Shi, C S; Leonardi A; Kyriakis J; Siebenlist U; Kehrl J H (September 1999). "TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related". J. Immunol. UNITED STATES. 163 (6): 3279–85. ISSN 0022-1767. PMID 10477597.

Oehrl W, Kardinal C, Ruf S, et al. (1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene. 17 (15): 1893–901. doi:10.1038/sj.onc.1202108. PMID 9788432.
Shi CS, Tuscano JM, Witte ON, Kehrl JH (1999). "GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway". Blood. 93 (4): 1338–45. doi:10.1182/blood.V93.4.1338. PMID 9949177.
Shi CS, Leonardi A, Kyriakis J, et al. (1999). "TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related". J. Immunol. 163 (6): 3279–85. PMID 10477597.
Chin AI, Shu J, Shan Shi C, et al. (2000). "TANK Potentiates Tumor Necrosis Factor Receptor-Associated Factor-Mediated c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase Activation through the Germinal Center Kinase Pathway". Mol. Cell. Biol. 19 (10): 6665–72. doi:10.1128/mcb.19.10.6665. PMC 84649. PMID 10490605.
Shi CS, Tuscano J, Kehrl JH (2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation". Blood. 95 (3): 776–82. doi:10.1182/blood.V95.3.776.003k23_776_782. PMID 10648385. S2CID 22593342.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shi CS, Kehrl JH (2003). "Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2)". J. Biol. Chem. 278 (17): 15429–34. doi:10.1074/jbc.M211796200. PMID 12591926.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gu Y, Luo T, Yang J, et al. (2006). "The -822G/A polymorphism in the promoter region of the MAP4K5 gene is associated with reduced risk of type 2 diabetes in Chinese Hans from Shanghai". J. Hum. Genet. 51 (7): 605–10. doi:10.1007/s10038-006-0402-9. PMID 16699725.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000012983 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034761 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9038372-5] Tung RM, Blenis J (March 1997). "A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase". Oncogene. 14 (6): 653–9. doi:10.1038/sj.onc.1200877. PMID 9038372.

[pmid8274451-6] Schultz SJ, Nigg EA (February 1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.

[entrez-7] "Entrez Gene: MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5".

[pmid10648385-8] Shi, C S; Tuscano J; Kehrl J H (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation". Blood. UNITED STATES. 95 (3): 776–82. doi:10.1182/blood.V95.3.776.003k23_776_782. ISSN 0006-4971. PMID 10648385. S2CID 22593342.

[pmid10477597-9] Shi, C S; Leonardi A; Kyriakis J; Siebenlist U; Kehrl J H (September 1999). "TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related". J. Immunol. UNITED STATES. 163 (6): 3279–85. ISSN 0022-1767. PMID 10477597.

MAP4K5

Interactions

References

Further reading