MCAT (gene)

Malonyl CoA-acyl carrier protein transacylase, mitochondrial is an enzyme that in humans is encoded by the MCAT gene.[5][6]

MCAT
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMCAT, FASN2C, MCT, MT, NET62, fabD, malonyl-CoA-acyl carrier protein transacylase, MCT1
External IDsOMIM: 614479 MGI: 2388651 HomoloGene: 15511 GeneCards: MCAT
Orthologs
SpeciesHumanMouse
Entrez

27349

223722

Ensembl

ENSG00000100294

ENSMUSG00000048755

UniProt

Q8IVS2

Q8R3F5

RefSeq (mRNA)

NM_014507
NM_173467

NM_001030014

RefSeq (protein)

NP_055322
NP_775738

NP_001025185

Location (UCSC)Chr 22: 43.13 – 43.14 MbChr 15: 83.43 – 83.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Two transcript variants encoding different isoforms have been found for this gene.[6]

Clinical significance

The enzyme encoded by the MCAT gene, along with other enzymes that regulate Malonyl-CoA concentration, have been shown to regulate levels such that malonyl-CoA concentration decreases in human muscle tissue when under exercise training. This enzyme specifically has increased activity under these conditions, as it is known to catabolize malonyl-CoA. [7]

Interactions

The human Malonyl CoA-acel carrier protein transacylase in human mitochondria associates with respiratory complex one, such that it interacts functionally with a mitochondrial malonyltransferase. Both species are encoded by nuclear genes, and their translocation into mitochondria is dependent on the presence of an N-terminal targeting sequence.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000100294 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000048755 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhang L, Joshi AK, Smith S (Oct 2003). "Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein". The Journal of Biological Chemistry. 278 (41): 40067–74. doi:10.1074/jbc.M306121200. PMID 12882974.
  6. "Entrez Gene: MCAT malonyl CoA:ACP acyltransferase (mitochondrial)".
  7. Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, Efendic S, Bavenholm PN (Jun 2006). "Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle". American Journal of Physiology. Endocrinology and Metabolism. 290 (6): E1296-303. doi:10.1152/ajpendo.00341.2005. PMID 16434556.

Further reading


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