MCC (gene)

Colorectal mutant cancer protein is a protein that in humans is encoded by the MCC gene.[5][6]

MCC
Identifiers
AliasesMCC, MCC1, mutated in colorectal cancers, WNT signaling pathway regulator, MCC regulator of WNT signaling pathway
External IDsOMIM: 159350 MGI: 96930 HomoloGene: 20539 GeneCards: MCC
Orthologs
SpeciesHumanMouse
Entrez

4163

328949

Ensembl

ENSG00000171444

ENSMUSG00000071856

UniProt

P23508

n/a

RefSeq (mRNA)

NM_001085377
NM_002387

NM_001033406
NM_001085373
NM_001085374

RefSeq (protein)

NP_001078846
NP_002378

n/a

Location (UCSC)Chr 5: 113.02 – 113.49 MbChr 18: 44.56 – 44.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000171444 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000071856 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A, et al. (Apr 1991). "Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers". Science. 251 (4999): 1366–70. Bibcode:1991Sci...251.1366K. doi:10.1126/science.1848370. PMID 1848370.
  6. "Entrez Gene: MCC mutated in colorectal cancers".

Further reading

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