MEAF6

MEAF6
Identifiers
Aliases	MEAF6, C1orf149, CENP-28, EAF6, NY-SAR-91, MYST/Esa1 associated factor 6
External IDs	OMIM: 611001 MGI: 1917338 HomoloGene: 11240 GeneCards: MEAF6
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	37,514,766 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	125,007,031 bp[2]
RNA expression pattern
	Top expressed in
	oocyte; ; ganglionic eminence; ; Achilles tendon; ; anterior pituitary; ; pons; ; secondary oocyte; ; islet of Langerhans; ; seminal vesicula; ; prefrontal cortex; ; bronchial epithelial cell;
	Top expressed in
	superior cervical ganglion; ; superior frontal gyrus; ; hand; ; neural tube; ; otolith organ; ; ganglionic eminence; ; utricle; ; morula; ; thymus; ; mirror;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; histone acetyltransferase activity (H3-K23 specific);
Cellular component	NuA4 histone acetyltransferase complex; MOZ/MORF histone acetyltransferase complex; histone acetyltransferase complex; nucleus; nucleolus; chromosome; kinetochore; chromosome, centromeric region; nucleoplasm; NuA3a histone acetyltransferase complex; NuA3b histone acetyltransferase complex;
Biological process	histone H4-K12 acetylation; regulation of transcription, DNA-templated; histone H4-K5 acetylation; histone acetylation; histone H4-K8 acetylation; histone H4-K16 acetylation; histone H3-K14 acetylation; histone H2A acetylation; transcription, DNA-templated; regulation of signal transduction by p53 class mediator; chromatin organization; histone H3-K23 acetylation;
	Sources:Amigo / QuickGO
Orthologs
	64769
	70088
	ENSG00000163875
	ENSMUSG00000028863
	Q9HAF1
	Q2VPQ9
	NM_001270875; NM_001270876; NM_022756
	NM_001290701; NM_027310; NM_001374123
	NP_001257804; NP_001257805; NP_073593
	NP_001277630; NP_081586; NP_001361052
	Wikidata
View/Edit Human	View/Edit Mouse

Chromatin modification-related protein MEAF6 is a protein that in humans is encoded by the MEAF6 gene.[5][6][7][8][9][10]

References

GRCh38: Ensembl release 89: ENSG00000163875 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028863 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW (Oct 2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J Biol Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
Doyon Y, Selleck W, Lane WS, Tan S, Cote J (Feb 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol Cell Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J (Jan 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Mol Cell. 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.
"Entrez Gene: C1orf149 chromosome 1 open reading frame 149".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lee SY, Obata Y, Yoshida M, et al. (2003). "Immunomic analysis of human sarcoma". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2651–6. Bibcode:2003PNAS..100.2651L. doi:10.1073/pnas.0437972100. PMC 151395. PMID 12601173.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163875 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028863 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8619474-5] Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[pmid9110174-6] Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.

[pmid12963728-7] Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW (Oct 2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J Biol Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.

[pmid14966270-8] Doyon Y, Selleck W, Lane WS, Tan S, Cote J (Feb 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol Cell Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.

[pmid16387653-9] Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J (Jan 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Mol Cell. 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.

[entrez-10] "Entrez Gene: C1orf149 chromosome 1 open reading frame 149".

MEAF6

References

Further reading