MEP1A

Meprin A subunit alpha also known as endopeptidase-2 or PABA peptide hydrolase is the alpha subunit of the meprin A enzyme that in humans is encoded by the MEP1A gene.[5][6] The MEP1A locus is on chromosome 6p in humans and on chromosome 17 in mice.[7]

MEP1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMEP1A, PPHA, meprin A subunit alpha
External IDsOMIM: 600388 MGI: 96963 HomoloGene: 31323 GeneCards: MEP1A
Orthologs
SpeciesHumanMouse
Entrez

4224

17287

Ensembl

ENSG00000112818

ENSMUSG00000023914

UniProt

Q16819

P28825

RefSeq (mRNA)

NM_005588

NM_008585

RefSeq (protein)

NP_005579

NP_032611

Location (UCSC)Chr 6: 46.79 – 46.84 MbChr 17: 43.79 – 43.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The meprin alpha subunit product of the MEP1A gene is processed in the endoplasmic reticulum during intracellular transport, and is secreted as homomeric meprin A. Meprin alpha subunits may self-associate, and once secreted, form very large multimers, with a molecular mass of over 1 million daltons. In cells concurrently expressing MEP1B, the meprin alpha and meprin beta subunits form disulfide dimers that interact to form membrane bound heterotetrameric meprin A.

References

  1. GRCh38: Ensembl release 89: ENSG00000112818 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023914 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bond JS, Rojas K, Overhauser J, Zoghbi HY, Jiang W (Jul 1995). "The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively". Genomics. 25 (1): 300–3. doi:10.1016/0888-7543(95)80142-9. PMID 7774936.
  6. "Entrez Gene: MEP1A meprin A, alpha (PABA peptide hydrolase)".
  7. Banerjee S, Oneda B, Yap LM, Jewell DP, Matters GL, Fitzpatrick LR, Seibold F, Sterchi EE, Ahmad T, Lottaz D, Bond JS (May 2009). "MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease". Mucosal Immunol. 2 (3): 220–31. doi:10.1038/mi.2009.3. PMC 2670347. PMID 19262505.

Further reading


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