MEPE

Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) is a protein that in humans is encoded by the MEPE gene.[5][6] A conserved RGD motif is found in this protein, and this is potentially involved in integrin recognition.[7]

MEPE
Identifiers
AliasesMEPE, OF45, matrix extracellular phosphoglycoprotein
External IDsOMIM: 605912 MGI: 2137384 HomoloGene: 10623 GeneCards: MEPE
Orthologs
SpeciesHumanMouse
Entrez

56955

94111

Ensembl

ENSG00000152595

ENSMUSG00000053863

UniProt

Q9NQ76

Q8K4L6

RefSeq (mRNA)

NM_053172

RefSeq (protein)

NP_444402

Location (UCSC)Chr 4: 87.82 – 87.85 MbChr 5: 104.47 – 104.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Osteoregulin
Identifiers
SymbolOsteoregulin
PfamPF07175
InterProIPR009837
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary


References

  1. GRCh38: Ensembl release 89: ENSG00000152595 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053863 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL (1 July 2000). "MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia". Genomics. 67 (1): 54–68. doi:10.1006/geno.2000.6235. PMID 10945470.
  6. "Entrez Gene: MEPE matrix, extracellular phosphoglycoprotein with ASARM motif (bone)".
  7. Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R, Brown TA (November 2000). "Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes". J. Biol. Chem. 275 (46): 36172–80. doi:10.1074/jbc.M003622200. PMID 10967096.

Further reading

This article incorporates text from the public domain Pfam and InterPro: IPR009837


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.