Mesoderm-specific transcript homolog protein

Mesoderm-specific transcript homolog protein is a protein that in humans is encoded by the MEST gene.[5][6]

MEST
Identifiers
AliasesMEST, PEG1, mesoderm specific transcript
External IDsOMIM: 601029 MGI: 96968 HomoloGene: 1800 GeneCards: MEST
Orthologs
SpeciesHumanMouse
Entrez

4232

17294

Ensembl

ENSG00000106484

ENSMUSG00000051855

UniProt

Q5EB52

Q07646

RefSeq (mRNA)

NM_001252292
NM_001252293
NM_008590

RefSeq (protein)

NP_001239221
NP_001239222
NP_032616

Location (UCSC)Chr 7: 130.49 – 130.51 MbChr 6: 30.72 – 30.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the Alpha/beta hydrolase superfamily and has isoform-specific imprinting. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promoter switching. The encoded protein may play a role in development. Three transcript variants encoding two distinct isoforms have been identified for this gene. A pseudogene for this locus is located on chromosome 6.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000106484 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000051855 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nishita Y, Yoshida I, Sado T, Takagi N (Feb 1997). "Genomic imprinting and chromosomal localization of the human MEST gene". Genomics. 36 (3): 539–42. doi:10.1006/geno.1996.0502. PMID 8884280.
  6. "Entrez Gene: MEST mesoderm specific transcript homolog (mouse)".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.