Mitochondrial fission factor

Mitochondrial fission factor (Mff) is a protein that in humans is encoded by the MFF gene.[3] Its primary role is in controlling the division of mitochondria. Mitochondrial morphology changes by continuous fission in order to create interconnected network of mitochondria. This activity is crucial for normal function of mitochondria.[4] It has also been shown to regulate peroxisome morphology.[5]

MFF
Identifiers
AliasesMFF, C2orf33, GL004, mitochondrial fission factor, EMPF2
External IDsOMIM: 614785 HomoloGene: 137341 GeneCards: MFF
Orthologs
SpeciesHumanMouse
Entrez

56947

n/a

Ensembl

ENSG00000168958

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UniProt

Q9GZY8

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 2: 227.33 – 227.36 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Role in mitochondrial fission
Main article: mitochondrial fission

Mff is an outer mitochondrial membrane protein that binds to the GTPase Drp1; the Mff-Drp1 complex is what promotes mitochondrial fission. Knockdown of Mff causes the mitochondrial network to expand (by releasing the Drp1 foci from the outer mitochondrial membrane), while Mff overexpression causes it to become fragmented (by stimulating mitochondrial recruitment of Drp1).[6] Mitochondrial fission factor plays a crucial role in engaging Drp1 to the outer mitochondrial membrane in order to direct mitochondrial fission.[7]


References
  1. GRCh38: Ensembl release 89: ENSG00000168958 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: mitochondrial fission factor".
  4. Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K (December 2010). "Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells". The Journal of Cell Biology. 191 (6): 1141–1158. doi:10.1083/jcb.201007152. PMC 3002033. PMID 21149567.
  5. Gandre-Babbe S, van der Bliek AM (June 2008). "The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells". Molecular Biology of the Cell. 19 (6): 2402–2412. doi:10.1091/mbc.E07-12-1287. PMC 2397315. PMID 18353969.
  6. Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K (December 2010). "Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells". The Journal of Cell Biology. 191 (6): 1141–1158. doi:10.1083/jcb.201007152. PMC 3002033. PMID 21149567.
  7. Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K (December 2010). "Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells". The Journal of Cell Biology. 191 (6): 1141–1158. doi:10.1083/jcb.201007152. PMC 3002033. PMID 21149567.

Further reading
  • Igci YZ, Arslan A, Akarsu E, Erkilic S, Igci M, Oztuzcu S, et al. (June 2011). "Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma". Endocrine Pathology. 22 (2): 86–96. doi:10.1007/s12022-011-9157-8. PMID 21509594. S2CID 11869197.
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