MFNG

Beta-1,3-N-acetylglucosaminyltransferase manic fringe is an enzyme that in humans is encoded by the MFNG gene,[5][6][7] a member of the fringe gene family which also includes the radical fringe (RFNG) and lunatic fringe (LFNG).[8][9]

MFNG
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMFNG, MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
External IDsOMIM: 602577 MGI: 1095404 HomoloGene: 1803 GeneCards: MFNG
Orthologs
SpeciesHumanMouse
Entrez

4242

17305

Ensembl

ENSG00000100060

ENSMUSG00000018169

UniProt

O00587

O09008

RefSeq (mRNA)

NM_001166343
NM_002405

NM_008595

RefSeq (protein)

NP_001159815
NP_002396

NP_032621

Location (UCSC)Chr 22: 37.47 – 37.49 MbChr 15: 78.64 – 78.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

They all encode evolutionarily conserved proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000100060 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018169 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Egan S, Herbrick JA, Tsui LC, Cohen B, Flock G, Beatty B, Scherer SW (Feb 1999). "Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12". Genomics. 54 (3): 576–7. doi:10.1006/geno.1998.5559. PMID 9878264.
  6. Johnston SH, Rauskolb C, Wilson R, Prabhakaran B, Irvine KD, Vogt TF (Jul 1997). "A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway". Development. 124 (11): 2245–54. doi:10.1242/dev.124.11.2245. PMID 9187150.
  7. "Entrez Gene: MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase".
  8. "Troublesome gene names get the boot", 6 November 2006, Michael Hopkin, nature.com
  9. "Sonic Hedgehog, DICER, and the Problem With Naming Genes", Sep 26, 2014, Michael White. psmag.com

Further reading


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