MFSD4A

MFSD4A
Identifiers
Aliases	MFSD4A, UNQ3064, MFSD4, major facilitator superfamily domain containing 4A, SLC60A1
External IDs	MGI: 2442786 HomoloGene: 45419 GeneCards: MFSD4A
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	205,602,918 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	131,995,800 bp[2]
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; renal medulla; ; middle temporal gyrus; ; Brodmann area 46; ; Brodmann area 23; ; endothelial cell; ; superior frontal gyrus; ; entorhinal cortex; ; postcentral gyrus; ; prefrontal cortex;
	Top expressed in
	epithelium of stomach; ; left colon; ; submandibular gland; ; aortic valve; ; ascending aorta; ; parotid gland; ; olfactory epithelium; ; cervix; ; mucous cell of stomach; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	glucose transmembrane transporter activity;
Cellular component	membrane; integral component of membrane;
Biological process	transmembrane transport; glucose transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	148808
	213006
	ENSG00000174514
	ENSMUSG00000059149
	Q8N468
	Q6PDC8
	NM_181644
	NM_001114662; NM_172510
	NP_857595
	NP_001108134; NP_766098
	Wikidata
View/Edit Human	View/Edit Mouse

Major facilitator superfamily domain containing 4A is a protein belonging to the MFS Pfam clan.[5] It is an atypical solute carrier, thus a plausible SLC transporter in humans.[6] MFSD4A has been identified in both central and peripheral areas.[7]

References

GRCh38: Ensembl release 89: ENSG00000174514 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000059149 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
Perland E, Hellsten SV, Schweizer N, Arapi V, Rezayee F, Bushra M, Fredriksson R (2017). "Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice". PLOS ONE. 12 (10): e0186325. Bibcode:2017PLoSO..1286325P. doi:10.1371/journal.pone.0186325. PMC 5648162. PMID 29049335.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174514 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059149 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.

[6] Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.

[7] Perland E, Hellsten SV, Schweizer N, Arapi V, Rezayee F, Bushra M, Fredriksson R (2017). "Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice". PLOS ONE. 12 (10): e0186325. Bibcode:2017PLoSO..1286325P. doi:10.1371/journal.pone.0186325. PMC 5648162. PMID 29049335.