MFSD5

MFSD5
Identifiers
Aliases	MFSD5, hsMOT2, major facilitator superfamily domain containing 5, SLC61A1
External IDs	MGI: 2145901 HomoloGene: 69517 GeneCards: MFSD5
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	53,254,406 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	102,190,189 bp[2]
RNA expression pattern
	Top expressed in
	skin of abdomen; ; left adrenal gland; ; gums; ; stromal cell of endometrium; ; cavity of mouth; ; monocyte; ; minor salivary gland; ; vagina; ; body of stomach; ; body of pancreas;
	Top expressed in
	lip; ; esophagus; ; calvaria; ; yolk sac; ; morula; ; hair follicle; ; conjunctival fornix; ; molar; ; epithelium of stomach; ; ankle joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; molybdate ion transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	molybdate ion transport; ion transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	84975
	106073
	ENSG00000182544
	ENSMUSG00000045665
	Q6N075
	Q921Y4
	NM_001170790; NM_032889
	NM_134100
	NP_001164261; NP_116278
	NP_598861
	Wikidata
View/Edit Human	View/Edit Mouse

Major facilitator superfamily domain containing 5 is an atypical SLC expressed in neuronal plasma membrane.[5] It is a plausible Solute carrier transporter.[6] It transports molybdate anions,[7] and it interacts with GLP-1R.[8]

MFSD5 belongs to AMTF6.[9]

References

GRCh38: Ensembl release 89: ENSG00000182544 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000045665 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
Tejada-Jiménez M, Galván A, Fernández E (April 2011). "Algae and humans share a molybdate transporter". Proceedings of the National Academy of Sciences of the United States of America. 108 (16): 6420–6425. Bibcode:2011PNAS..108.6420T. doi:10.1073/pnas.1100700108. PMC 3080982. PMID 21464289.
Huang X, Dai FF, Gaisano G, Giglou K, Han J, Zhang M, et al. (September 2013). "The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity". Molecular Endocrinology. 27 (9): 1550–1563. doi:10.1210/me.2013-1047. PMC 5415235. PMID 23864651.
Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182544 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045665 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.

[6] Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.

[7] Tejada-Jiménez M, Galván A, Fernández E (April 2011). "Algae and humans share a molybdate transporter". Proceedings of the National Academy of Sciences of the United States of America. 108 (16): 6420–6425. Bibcode:2011PNAS..108.6420T. doi:10.1073/pnas.1100700108. PMC 3080982. PMID 21464289.

[8] Huang X, Dai FF, Gaisano G, Giglou K, Han J, Zhang M, et al. (September 2013). "The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity". Molecular Endocrinology. 27 (9): 1550–1563. doi:10.1210/me.2013-1047. PMC 5415235. PMID 23864651.

[9] Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.