MGAT1

MGAT1
Identifiers
Aliases	MGAT1, GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, MGAT, GnTI, mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
External IDs	OMIM: 160995 MGI: 96973 HomoloGene: 1804 GeneCards: MGAT1
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	180,815,652 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	49,153,857 bp[2]
RNA expression pattern
	Top expressed in
	monocyte; ; right lung; ; gastric mucosa; ; upper lobe of left lung; ; right lobe of thyroid gland; ; left uterine tube; ; spleen; ; left lobe of thyroid gland; ; body of pancreas; ; right coronary artery;
	Top expressed in
	thymus; ; yolk sac; ; proximal tubule; ; molar; ; lip; ; calvaria; ; right ventricle; ; temporal muscle; ; spleen; ; entorhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; acetylglucosaminyltransferase activity; metal ion binding; alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity; manganese ion binding;
Cellular component	integral component of membrane; extracellular vesicle; Golgi membrane; Golgi apparatus; extracellular exosome; membrane;
Biological process	protein glycosylation; in utero embryonic development; UDP-N-acetylglucosamine catabolic process; carbohydrate metabolic process; protein N-linked glycosylation; protein N-linked glycosylation via asparagine;
	Sources:Amigo / QuickGO
Orthologs
	4245
	17308
	ENSG00000131446
	ENSMUSG00000020346
	P26572
	P27808
	NM_001114617; NM_001114618; NM_001114619; NM_001114620; NM_002406
	NM_001110148; NM_001110149; NM_001110150; NM_010794
NP_001108089; NP_001108090; NP_001108091; NP_001108092; NP_002397;
	NP_001351306; NP_001351308; NP_001351309; NP_001351310; NP_001351311; NP_001351312; NP_001351313; NP_001351314; NP_001351315; NP_001351316; NP_001351317; NP_001351318; NP_001351319; NP_001351320; NP_001351321; NP_001351322; NP_001351323; NP_001351324
	NP_001103618; NP_001103619; NP_001103620; NP_034924
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT1 gene.[5][6]

There are over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis.[6]

References

GRCh38: Ensembl release 89: ENSG00000131446 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020346 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hull E, Sarkar M, Spruijt MP, Hoppener JW, Dunn R, Schachter H (Jun 1991). "Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene". Biochem Biophys Res Commun. 176 (2): 608–15. doi:10.1016/S0006-291X(05)80227-X. PMID 1827260.
"Entrez Gene: MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase".

Kumar R, Yang J, Eddy RL, et al. (1992). "Cloning and expression of the murine gene and chromosomal location of the human gene encoding N-acetylglucosaminyltransferase I". Glycobiology. 2 (4): 383–93. doi:10.1093/glycob/2.4.383. PMID 1421759.
Kumar R, Yang J, Larsen RD, Stanley P (1991). "Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9948–52. doi:10.1073/pnas.87.24.9948. PMC 55291. PMID 1702225.
Tan J, D'Agostaro AF, Bendiak B, et al. (1995). "The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein". Eur. J. Biochem. 231 (2): 317–28. doi:10.1111/j.1432-1033.1995.tb20703.x. PMID 7635144.
Yip B, Chen SH, Mulder H, et al. (1997). "Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis". Biochem. J. 321 (2): 465–74. doi:10.1042/bj3210465. PMC 1218092. PMID 9020882.
Yen CL, Stone SJ, Cases S, et al. (2002). "Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase". Proc. Natl. Acad. Sci. U.S.A. 99 (13): 8512–7. Bibcode:2002PNAS...99.8512Y. doi:10.1073/pnas.132274899. PMC 124292. PMID 12077311.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Saribas AS, Johnson K, Liu L, et al. (2007). "Refolding of human beta-1-2 GlcNAc transferase (GnT1) and the role of its unpaired Cys 121". Biochem. Biophys. Res. Commun. 362 (2): 381–6. doi:10.1016/j.bbrc.2007.07.199. PMID 17716624.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131446 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020346 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1827260-5] Hull E, Sarkar M, Spruijt MP, Hoppener JW, Dunn R, Schachter H (Jun 1991). "Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene". Biochem Biophys Res Commun. 176 (2): 608–15. doi:10.1016/S0006-291X(05)80227-X. PMID 1827260.

[entrez-6] "Entrez Gene: MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase".

MGAT1

References

Further reading