MGAT1

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT1 gene.[5][6]

MGAT1
Identifiers
AliasesMGAT1, GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, MGAT, GnTI, mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
External IDsOMIM: 160995 MGI: 96973 HomoloGene: 1804 GeneCards: MGAT1
Orthologs
SpeciesHumanMouse
Entrez

4245

17308

Ensembl

ENSG00000131446

ENSMUSG00000020346

UniProt

P26572

P27808

RefSeq (mRNA)

NM_001114617
NM_001114618
NM_001114619
NM_001114620
NM_002406

NM_001110148
NM_001110149
NM_001110150
NM_010794

RefSeq (protein)

NP_001103618
NP_001103619
NP_001103620
NP_034924

Location (UCSC)Chr 5: 180.78 – 180.82 MbChr 11: 49.14 – 49.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

There are over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000131446 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020346 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hull E, Sarkar M, Spruijt MP, Hoppener JW, Dunn R, Schachter H (Jun 1991). "Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene". Biochem Biophys Res Commun. 176 (2): 608–15. doi:10.1016/S0006-291X(05)80227-X. PMID 1827260.
  6. "Entrez Gene: MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase".

Further reading


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