MGAT3

Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT3 gene.[5][6]

MGAT3
Identifiers
AliasesMGAT3, GNT-III, GNT3, mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
External IDsOMIM: 604621 MGI: 104532 HomoloGene: 31088 GeneCards: MGAT3
Orthologs
SpeciesHumanMouse
Entrez

4248

17309

Ensembl

ENSG00000128268

ENSMUSG00000042428

UniProt

Q09327

Q10470
Q5RKT9

RefSeq (mRNA)

NM_001098270
NM_002409

NM_010795

RefSeq (protein)

NP_001091740
NP_002400

NP_034925

Location (UCSC)Chr 22: 39.46 – 39.49 MbChr 15: 80.06 – 80.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000128268 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000042428 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ihara Y, Nishikawa A, Tohma T, Soejima H, Niikawa N, Taniguchi N (Oct 1993). "cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III)". J Biochem. 113 (6): 692–8. doi:10.1093/oxfordjournals.jbchem.a124105. PMID 8370666.
  6. "Entrez Gene: MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase".

Further reading

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