MGST3

Microsomal glutathione S-transferase 3 is an enzyme that in humans is encoded by the MGST3 gene.[5][6]

MGST3
Identifiers
AliasesMGST3, GST-III, microsomal glutathione S-transferase 3
External IDsOMIM: 604564 MGI: 1913697 HomoloGene: 3327 GeneCards: MGST3
Orthologs
SpeciesHumanMouse
Entrez

4259

66447

Ensembl

ENSG00000143198

ENSMUSG00000026688

UniProt

O14880

Q9CPU4

RefSeq (mRNA)

NM_004528

NM_025569
NM_029392

RefSeq (protein)

NP_004519

NP_079845

Location (UCSC)Chr 1: 165.63 – 165.66 MbChr 1: 167.2 – 167.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[6]

Model organisms

Model organisms have been used in the study of MGST3 function. A conditional knockout mouse line, called Mgst3tm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000143198 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026688 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW (Oct 1997). "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities". J Biol Chem. 272 (36): 22934–9. doi:10.1074/jbc.272.36.22934. PMID 9278457.
  6. "Entrez Gene: MGST3 microsomal glutathione S-transferase 3".
  7. "Salmonella infection data for Mgst3". Wellcome Trust Sanger Institute.
  8. "Citrobacter infection data for Mgst3". Wellcome Trust Sanger Institute.
  9. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  10. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. "International Knockout Mouse Consortium".
  12. "Mouse Genome Informatics".
  13. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  15. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  16. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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