MINK1

Misshapen-like kinase 1 is an enzyme that in humans is encoded by the MINK1 gene.[5][6][7]

MINK1
Identifiers
AliasesMINK1, B55, MAP4K6, MINK, YSK2, ZC3, hMINK, hMINKbeta, misshapen like kinase 1
External IDsOMIM: 609426 MGI: 1355329 HomoloGene: 56762 GeneCards: MINK1
Orthologs
SpeciesHumanMouse
Entrez

50488

50932

Ensembl

ENSG00000141503

ENSMUSG00000020827

UniProt

Q8N4C8

Q9JM52

RefSeq (mRNA)

NM_001024937
NM_015716
NM_153827
NM_170663
NM_001321236

NM_001045959
NM_001045964
NM_016713
NM_176893

RefSeq (protein)

NP_001020108
NP_001308165
NP_056531
NP_722549
NP_733763

Location (UCSC)Chr 17: 4.83 – 4.9 MbChr 11: 70.45 – 70.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Misshapen-like kinase 1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.[7]

Interactions

MINK1 has been shown to interact with NCK1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000141503 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020827 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dan I, Watanabe NM, Kobayashi T, Yamashita-Suzuki K, Fukagaya Y, Kajikawa E, Kimura WK, Nakashima TM, Matsumoto K, Ninomiya-Tsuji J, Kusumi A (Mar 2000). "Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development". FEBS Letters. 469 (1): 19–23. doi:10.1016/S0014-5793(00)01247-3. PMID 10708748. S2CID 39793431.
  6. Dan I, Watanabe NM, Kajikawa E, Ishida T, Pandey A, Kusumi A (Jul 2002). "Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution". Nucleic Acids Research. 30 (13): 2906–10. doi:10.1093/nar/gkf407. PMC 117062. PMID 12087176.
  7. "Entrez Gene: MINK1 misshapen-like kinase 1 (zebrafish)".
  8. Hu Y, Leo C, Yu S, Huang BC, Wang H, Shen M, Luo Y, Daniel-Issakani S, Payan DG, Xu X (Dec 2004). "Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta". The Journal of Biological Chemistry. 279 (52): 54387–97. doi:10.1074/jbc.M404497200. PMID 15469942.

Further reading

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