MIR106A
MicroRNA 106a is a microRNA that in humans is encoded by the MIR106A gene. [3]
| MIR106A | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | MIR106A, MIRN106A, mir-106, mir-106a, microRNA 106a | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 300792 GeneCards: MIR106A | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.
The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.
The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
References
- GRCh38: Ensembl release 89: ENSG00000284157 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: MicroRNA 106a". Retrieved 2017-11-13.
Further reading
- Sharma A, Kumar M, Aich J, Hariharan M, Brahmachari SK, Agrawal A, Ghosh B (2009). "Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a". Proc. Natl. Acad. Sci. U.S.A. 106 (14): 5761–6. Bibcode:2009PNAS..106.5761S. doi:10.1073/pnas.0808743106. PMC 2659714. PMID 19307576.
- Hackl M, Brunner S, Fortschegger K, Schreiner C, Micutkova L, Mück C, Laschober GT, Lepperdinger G, Sampson N, Berger P, Herndler-Brandstetter D, Wieser M, Kühnel H, Strasser A, Rinnerthaler M, Breitenbach M, Mildner M, Eckhart L, Tschachler E, Trost A, Bauer JW, Papak C, Trajanoski Z, Scheideler M, Grillari-Voglauer R, Grubeck-Loebenstein B, Jansen-Dürr P, Grillari J (2010). "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging". Aging Cell. 9 (2): 291–6. doi:10.1111/j.1474-9726.2010.00549.x. PMC 2848978. PMID 20089119.
- Zhou H, Guo JM, Lou YR, Zhang XJ, Zhong FD, Jiang Z, Cheng J, Xiao BX (2010). "Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker". J. Mol. Med. 88 (7): 709–17. doi:10.1007/s00109-010-0617-2. PMID 20349219. S2CID 13285873.
- Hummel R, Hussey DJ, Michael MZ, Haier J, Bruewer M, Senninger N, Watson DI (2011). "MiRNAs and their association with locoregional staging and survival following surgery for esophageal carcinoma". Ann. Surg. Oncol. 18 (1): 253–60. doi:10.1245/s10434-010-1213-y. PMID 20628822. S2CID 26439245.
- Jiang X, Li N (2011). "Induction of MiR-17-3p and MiR-106a [corrected] by TNFα and LPS". Cell Biochem. Funct. 29 (2): 164–70. doi:10.1002/cbf.1728. PMID 21370248. S2CID 26310852.
- Liao B, Bao X, Liu L, Feng S, Zovoilis A, Liu W, Xue Y, Cai J, Guo X, Qin B, Zhang R, Wu J, Lai L, Teng M, Niu L, Zhang B, Esteban MA, Pei D (2011). "MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition". J. Biol. Chem. 286 (19): 17359–64. doi:10.1074/jbc.C111.235960. PMC 3089577. PMID 21454525.
- Yang G, Zhang R, Chen X, Mu Y, Ai J, Shi C, Liu Y, Shi C, Sun L, Rainov NG, Li H, Yang B, Zhao S (2011). "MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status". J. Mol. Med. 89 (10): 1037–50. doi:10.1007/s00109-011-0775-x. PMID 21656380. S2CID 26039378.
- Wang Z, Liu M, Zhu H, Zhang W, He S, Hu C, Quan L, Bai J, Xu N (2013). "miR-106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS". Mol. Carcinog. 52 (8): 634–46. doi:10.1002/mc.21899. PMID 22431000. S2CID 22089497.
- Feng B, Dong TT, Wang LL, Zhou HM, Zhao HC, Dong F, Zheng MH (2012). "Colorectal cancer migration and invasion initiated by microRNA-106a". PLOS ONE. 7 (8): e43452. Bibcode:2012PLoSO...743452F. doi:10.1371/journal.pone.0043452. PMC 3422256. PMID 22912877.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.