MIR1271
MicroRNA 1271 is a microRNA that in humans is encoded by the MIR1271 gene. [3]
| MIR1271 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MIR1271, MIRN1271, hsa-mir-1271, microRNA 1271 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | GeneCards: MIR1271 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.
The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.
The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.
References
- GRCh38: Ensembl release 89: ENSG00000221464 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: MicroRNA 1271". Retrieved 2017-02-19.
Further reading
- Maurel M, Jalvy S, Ladeiro Y, Combe C, Vachet L, Sagliocco F, Bioulac-Sage P, Pitard V, Jacquemin-Sablon H, Zucman-Rossi J, Laloo B, Grosset CF (2013). "A functional screening identifies five microRNAs controlling glypican-3: role of miR-1271 down-regulation in hepatocellular carcinoma". Hepatology. 57 (1): 195–204. doi:10.1002/hep.25994. PMID 22865282. S2CID 205885639.
- Yang M, Shan X, Zhou X, Qiu T, Zhu W, Ding Y, Shu Y, Liu P (2014). "miR-1271 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R, IRS1, mTOR, and BCL2". Anticancer Agents Med Chem. 14 (6): 884–91. doi:10.2174/1871520614666140528161318. PMID 24875127.
- Wang Y, Xu L, Jiang L (2015). "miR-1271 promotes non-small-cell lung cancer cell proliferation and invasion via targeting HOXA5". Biochem. Biophys. Res. Commun. 458 (3): 714–9. doi:10.1016/j.bbrc.2015.02.033. PMID 25686496.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.