MIR146A
MicroRNA 146a is a small non-coding RNA that in humans is encoded by the MIR146A gene.[3]
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| Aliases | MIR146A, MIRN146, MIRN146A, miR-146a, miRNA146A, microRNA 146a | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 610566 GeneCards: MIR146A | ||||||||||||||||||||||||||||||||||||||||||||||||||
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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.[3]
References
- GRCh38: Ensembl release 89: ENSG00000283733 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: MicroRNA 146a". Retrieved 2012-01-27.
Further reading
- Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (April 2002). "Identification of tissue-specific microRNAs from mouse". Current Biology. 12 (9): 735–9. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
- Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR (April 2005). "Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells". Proceedings of the National Academy of Sciences of the United States of America. 102 (15): 5570–5. Bibcode:2005PNAS..102.5570C. doi:10.1073/pnas.0408192102. PMC 556237. PMID 15800047.
- He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S, Calin GA, Liu CG, Franssila K, Suster S, Kloos RT, Croce CM, de la Chapelle A (December 2005). "The role of microRNA genes in papillary thyroid carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 102 (52): 19075–80. Bibcode:2005PNAS..10219075H. doi:10.1073/pnas.0509603102. PMC 1323209. PMID 16365291.
- Taganov KD, Boldin MP, Chang KJ, Baltimore D (August 2006). "NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses". Proceedings of the National Academy of Sciences of the United States of America. 103 (33): 12481–6. Bibcode:2006PNAS..10312481T. doi:10.1073/pnas.0605298103. PMC 1567904. PMID 16885212.
- Sonkoly E, Wei T, Janson PC, Sääf A, Lundeberg L, Tengvall-Linder M, Norstedt G, Alenius H, Homey B, Scheynius A, Ståhle M, Pivarcsi A (July 2007). Zimmer J (ed.). "MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?". PLOS ONE. 2 (7): e610. Bibcode:2007PLoSO...2..610S. doi:10.1371/journal.pone.0000610. PMC 1905940. PMID 17622355.
- Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X, Lin Z, Schaefer BC, Flemington EK (February 2008). "Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways". Journal of Virology. 82 (4): 1946–58. doi:10.1128/JVI.02136-07. PMC 2258704. PMID 18057241.
- Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D (April 2008). "Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis". Arthritis and Rheumatism. 58 (4): 1001–9. doi:10.1002/art.23386. PMID 18383392.
- Perry MM, Moschos SA, Williams AE, Shepherd NJ, Larner-Svensson HM, Lindsay MA (April 2008). "Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells". Journal of Immunology. 180 (8): 5689–98. doi:10.4049/jimmunol.180.8.5689. PMC 2639646. PMID 18390754.
- Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR, de la Chapelle A (May 2008). "Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 105 (20): 7269–74. Bibcode:2008PNAS..105.7269J. doi:10.1073/pnas.0802682105. PMC 2438239. PMID 18474871.
- Labbaye C, Spinello I, Quaranta MT, Pelosi E, Pasquini L, Petrucci E, Biffoni M, Nuzzolo ER, Billi M, Foà R, Brunetti E, Grignani F, Testa U, Peschle C (July 2008). "A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis". Nature Cell Biology. 10 (7): 788–801. doi:10.1038/ncb1741. PMID 18568019. S2CID 30191805.
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