MIR223
MicroRNA 223 is a protein that in humans is encoded by the MIR223 gene. [3]
| MIR223 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | MIR223, MIRN223, miRNA223, mir-223, microRNA 223 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 300694 GeneCards: MIR223 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.
The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.
The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
References
- GRCh38: Ensembl release 89: ENSG00000284567 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: MicroRNA 223". Retrieved 2018-08-29.
Further reading
- Fazi F, Racanicchi S, Zardo G, Starnes LM, Mancini M, Travaglini L, Diverio D, Ammatuna E, Cimino G, Lo-Coco F, Grignani F, Nervi C (November 2007). "Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein". Cancer Cell. 12 (5): 457–66. doi:10.1016/j.ccr.2007.09.020. PMID 17996649.
- Laios A, O'Toole S, Flavin R, Martin C, Kelly L, Ring M, Finn SP, Barrett C, Loda M, Gleeson N, D'Arcy T, McGuinness E, Sheils O, Sheppard B, O' Leary J (April 2008). "Potential role of miR-9 and miR-223 in recurrent ovarian cancer". Mol. Cancer. 7: 35. doi:10.1186/1476-4598-7-35. PMC 2383925. PMID 18442408.
- Wong QW, Lung RW, Law PT, Lai PB, Chan KY, To KF, Wong N (July 2008). "MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1". Gastroenterology. 135 (1): 257–69. doi:10.1053/j.gastro.2008.04.003. PMID 18555017.
- Yuan JY, Wang F, Yu J, Yang GH, Liu XL, Zhang JW (2009). "MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells". J. Cell. Mol. Med. 13 (11–12): 4551–9. doi:10.1111/j.1582-4934.2008.00585.x. PMC 4515070. PMID 19017354.
- Malumbres R, Sarosiek KA, Cubedo E, Ruiz JW, Jiang X, Gascoyne RD, Tibshirani R, Lossos IS (April 2009). "Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas". Blood. 113 (16): 3754–64. doi:10.1182/blood-2008-10-184077. PMC 2670792. PMID 19047678.
- Shen J, Ambrosone CB, Zhao H (March 2009). "Novel genetic variants in microRNA genes and familial breast cancer". Int. J. Cancer. 124 (5): 1178–82. doi:10.1002/ijc.24008. PMID 19048628.
- Stamatopoulos B, Meuleman N, Haibe-Kains B, Saussoy P, Van Den Neste E, Michaux L, Heimann P, Martiat P, Bron D, Lagneaux L (May 2009). "microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification". Blood. 113 (21): 5237–45. doi:10.1182/blood-2008-11-189407. PMID 19144983.
- Rainer J, Ploner C, Jesacher S, Ploner A, Eduardoff M, Mansha M, Wasim M, Panzer-Grümayer R, Trajanoski Z, Niederegger H, Kofler R (April 2009). "Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia". Leukemia. 23 (4): 746–52. doi:10.1038/leu.2008.370. PMID 19148136.
- Felli N, Pedini F, Romania P, Biffoni M, Morsilli O, Castelli G, Santoro S, Chicarella S, Sorrentino A, Peschle C, Marziali G (April 2009). "MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis". Haematologica. 94 (4): 479–86. doi:10.3324/haematol.2008.002345. PMC 2663611. PMID 19278969.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.