MMEL1

Membrane metallo-endopeptidase-like 1 is a protein that in humans is encoded by the MMEL1 gene.[5]

MMEL1
Identifiers
AliasesMMEL1, MMEL2, NEP2, NEPII, NL1, NL2, SEP, membrane metallo-endopeptidase-like 1, membrane metalloendopeptidase like 1
External IDsOMIM: 618104 MGI: 1351603 HomoloGene: 22778 GeneCards: MMEL1
Orthologs
SpeciesHumanMouse
Entrez

79258

27390

Ensembl

ENSG00000142606
ENSG00000277131

ENSMUSG00000058183

UniProt

Q495T6

Q9JLI3

RefSeq (mRNA)

NM_033467

NM_013783

RefSeq (protein)

NP_258428

NP_038811

Location (UCSC)Chr 1: 2.59 – 2.63 MbChr 4: 154.95 – 154.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.

References

  1. ENSG00000277131 GRCh38: Ensembl release 89: ENSG00000142606, ENSG00000277131 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000058183 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Membrane metallo-endopeptidase-like 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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