MPP2

MAGUK p55 subfamily member 2 is a protein that in humans is encoded by the MPP2 gene.[5][6]

MPP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMPP2, DLG2, membrane palmitoylated protein 2, MAGUK p55 scaffold protein 2
External IDsOMIM: 600723 MGI: 1858257 HomoloGene: 3920 GeneCards: MPP2
Orthologs
SpeciesHumanMouse
Entrez

4355

50997

Ensembl

ENSG00000108852

ENSMUSG00000017314

UniProt

Q14168

Q9WV34

RefSeq (mRNA)

NM_016695
NM_001356324

RefSeq (protein)

NP_057904
NP_001343253

Location (UCSC)Chr 17: 43.88 – 43.91 MbChr 11: 101.95 – 101.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000108852 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000017314 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mazoyer S, Gayther SA, Nagai MA, Smith SA, Dunning A, van Rensburg EJ, Albertsen H, White R, Ponder BA (Dec 1995). "A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A". Genomics. 28 (1): 25–31. doi:10.1006/geno.1995.1101. PMID 7590743.
  6. "Entrez Gene: MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.