mRNA (guanine-N7-)-methyltransferase

In enzymology, a mRNA (guanine-N7-)-methyltransferase also known as mRNA cap guanine-N7 methyltransferase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + G(5')pppR-RNA S-adenosyl-L-homocysteine + m7G(5')pppR-RNA (mRNA containing an N7-methylguanine cap)
mRNA (guanine-N7-)-methyltransferase
Identifiers
EC no.2.1.1.56
CAS no.56941-25-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
RNMT
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNMT, MET, RG7MT1, hCMT1c, CMT1, CMT1c, cm1p, hCMT1, hMet, MRNA-methyltransferase, RNA guanine-7 methyltransferase, N7-MTase
External IDsOMIM: 603514 MGI: 1915147 HomoloGene: 2816 GeneCards: RNMT
Orthologs
SpeciesHumanMouse
Entrez

8731

67897

Ensembl

ENSG00000101654

ENSMUSG00000009535

UniProt

O43148

Q9D0L8

RefSeq (mRNA)

NM_001308263
NM_003799
NM_001378132
NM_001378134
NM_001378135

NM_001170953
NM_026440
NM_001361002
NM_001361003

RefSeq (protein)

NP_001295192
NP_003790
NP_001365061
NP_001365063
NP_001365064

NP_001164424
NP_080716
NP_001347931
NP_001347932

Location (UCSC)Chr 18: 13.73 – 13.76 MbChr 18: 68.43 – 68.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thus, the two substrates of this enzyme are S-adenosyl methionine and G(5')pppR-RNA, whereas its two products are S-adenosylhomocysteine and m7G(5')pppR-RNA. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases.

In humans, mRNA cap guanine-N7 methyltransferase is encoded by the RNMT gene.[5][6][7]

Nomenclature

The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase. Other names in common use include:

  • messenger ribonucleate guanine 7-methyltransferase,
  • guanine-7-methyltransferase,
  • messenger RNA guanine 7-methyltransferase, and
  • S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase.
  • cap MTase

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000101654 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000009535 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (Jan 1999). "Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively". Genomics. 54 (2): 351–3. doi:10.1006/geno.1998.5604. PMID 9828141.
  6. Pillutla RC, Yue Z, Maldonado E, Shatkin AJ (Sep 1998). "Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes". J Biol Chem. 273 (34): 21443–6. doi:10.1074/jbc.273.34.21443. PMID 9705270.
  7. "Entrez Gene: RNMT RNA (guanine-7-) methyltransferase".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.