MTCP1

Protein p13 MTCP-1 is a protein that in humans is encoded by the MTCP1 gene.[3][4][5][6]

MTCP1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMTCP1, P13p8mature T-cell proliferation 1, mature T cell proliferation 1, TCL1C
External IDsOMIM: 300116 HomoloGene: 82921 GeneCards: MTCP1
Orthologs
SpeciesHumanMouse
Entrez

4515

n/a

Ensembl

ENSG00000214827

n/a

UniProt

P56278

n/a

RefSeq (mRNA)

NM_014221
NM_001018025

n/a

RefSeq (protein)

NP_001018025

n/a

Location (UCSC)Chr X: 155.06 – 155.15 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. The gene has two ORFs that encode two different proteins. The upstream ORF encodes a 13kDa protein that is a member of the TCL1 family; this protein may be involved in leukemogenesis. The downstream ORF encodes an 8kDa protein that localizes to mitochondria. Alternative splicing results in multiple transcript variants.[6]

Interactions

MTCP1 has been shown to interact with AKT1.[7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000214827 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Stern MH, Soulier J, Rosenzwajg M, Nakahara K, Canki-Klain N, Aurias A, Sigaux F, Kirsch IR (September 1993). "MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations". Oncogene. 8 (9): 2475–83. PMID 8361760.
  4. Madani A, Choukroun V, Soulier J, Cacheux V, Claisse JF, Valensi F, Daliphard S, Cazin B, Levy V, Leblond V, Daniel MT, Sigaux F, Stern MH (July 1996). "Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations". Blood. 87 (5): 1923–7. doi:10.1182/blood.V87.5.1923.1923. PMID 8634440.
  5. Yang YS, Guignard L, Padilla A, Hoh F, Strub MP, Stern MH, Lhoste JM, Roumestand C (September 1998). "Solution structure of the recombinant human oncoprotein p13MTCP1". J Biomol NMR. 11 (3): 337–54. doi:10.1023/A:1008279616063. PMID 9691281. S2CID 22862333.
  6. "Entrez Gene: MTCP1 mature T-cell proliferation 1".
  7. Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
  8. Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.