Mitochondrial translational release factor 1

Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.[5][6]

MTRF1
Identifiers
AliasesMTRF1, MRF1, MTTRF1, RF1, mitochondrial translational release factor 1, mitochondrial translation release factor 1
External IDsOMIM: 604601 MGI: 2384815 HomoloGene: 20903 GeneCards: MTRF1
Orthologs
SpeciesHumanMouse
Entrez

9617

211253

Ensembl

ENSG00000120662

ENSMUSG00000022022

UniProt

O75570
Q8N6Z2

Q8K126

RefSeq (mRNA)

NM_004294
NM_001354073
NM_001354074
NM_001354076

NM_145960

RefSeq (protein)

NP_004285
NP_001341002
NP_001341003
NP_001341005

NP_666072

Location (UCSC)Chr 13: 41.22 – 41.26 MbChr 14: 79.64 – 79.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.

References

  1. GRCh38: Ensembl release 89: ENSG00000120662 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022022 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhang Y, Spremulli LL (November 1998). "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (1–2): 245–50. doi:10.1016/S0167-4781(98)00223-1. PMID 9838146.
  6. Hansen LL, Jørgensen R, Justesen J (2000). "Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping". Cytogenetics and Cell Genetics. 88 (1–2): 91–2. doi:10.1159/000015494. PMID 10773675. S2CID 1354562.

Further reading


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