MUPCDH

Mucin and cadherin-like protein is a protein that in humans is encoded by the MUPCDH gene.[5][6][7]

CDHR5
Identifiers
AliasesCDHR5, MU-PCDH, MUCDHL, MUPCDH, MLPCDH, cadherin related family member 5
External IDsOMIM: 606839 MGI: 1919290 HomoloGene: 69345 GeneCards: CDHR5
Orthologs
SpeciesHumanMouse
Entrez

53841

72040

Ensembl

ENSG00000099834
ENSG00000273572

ENSMUSG00000025497

UniProt

Q9HBB8

Q8VHF2

RefSeq (mRNA)

NM_001171968
NM_017717
NM_021924
NM_031264
NM_031265

NM_001114322
NM_028069

RefSeq (protein)

NP_001165439
NP_068743
NP_112554

NP_001107794
NP_082345

Location (UCSC)Chr 11: 0.62 – 0.63 MbChr 7: 140.85 – 140.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternative splicing has been identified, with observed variation resulting in the presence or absence of domains. In addition, splicing occurs in the 5' UTR but transcripts including these variations have not been described completely.[7]

References

  1. ENSG00000273572 GRCh38: Ensembl release 89: ENSG00000099834, ENSG00000273572 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025497 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Paris MJ, Williams BR (Jan 2001). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics. 69 (2): 196–202. doi:10.1006/geno.2000.6339. PMID 11031102.
  6. Goldberg M, Peshkovsky C, Shifteh A, Al-Awqati Q (Sep 2000). "mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains". J Biol Chem. 275 (32): 24622–9. doi:10.1074/jbc.M000234200. PMID 10801787. S2CID 42493271.
  7. "Entrez Gene: MUCDHL mucin and cadherin-like".

Further reading


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