Malate—CoA ligase

In enzymology, a malate—CoA ligase (EC 6.2.1.9) is an enzyme that catalyzes the chemical reaction

ATP + malate + CoA ADP + phosphate + malyl-CoA
Malate—CoA ligase
Identifiers
EC no.6.2.1.9
CAS no.37318-58-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The 3 substrates of this enzyme are ATP, malate, and CoA, whereas its 3 products are ADP, phosphate, and malyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is malate:CoA ligase (ADP-forming). Other names in common use include malyl-CoA synthetase, malyl coenzyme A synthetase, and malate thiokinase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

References

    • Mue S, Tuboi S, Kikuchi G (December 1964). "On malyl-coenzyme A synthetase". J. Biochem. 56: 545–551. PMID 14244056.


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